Artificial Dynamic Structure Ensemble-Guided Rational Design of a Universal RNA Aptamer–Based Sensing Tag

Life Sciences, Biochemistry, Bioengineering, Genetics, Biophysics,
Artificial RNA   Dynamic Structure Ensemble   Fluorogenic RNA Aptamer   Biosensing   Gene Editing  

Artificial Dynamic RNA Structure Ensemble-Guided Rational Design of a Universal RNA Aptamer-Based Sensing Tag Academic Background RNA molecules play versatile roles in both natural and synthetic biological systems, with their functions strongly dependent on their dynamic and specific three-dimensional structures. RNA secondary and tertiary structur...

Tumor Analysis of BRCA Carriers Reveals Genomic Similarities Despite Temporal Separation

Medicine, Basic Medical Sciences, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
BRCA   breast cancer   genomic profile   molecular analysis   early life events   genetic modifiers   preventive medicine  

Tumor Analysis of BRCA1/2 Carriers: Genomic Similarities Evident Across Different Time Points Breast cancer (BC) is the most common malignant tumor among women globally, with its pathogenesis predominantly sporadic, while familial hereditary cases account for only 5% to 10%. Among various pathogenic molecules, mutations in the BRCA1/2 genes (Pathog...

The Role of Radioresistant-Related Telomere Genes in the Prognosis and Immune Infiltration of Lung Adenocarcinoma

Medicine, Respiratory System, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
lung adenocarcinoma   radiotherapy   telomere genes   immune infiltration   prognostic model  

The Impact of Radioresistant-Related Telomere Genes on Prognosis and Immune Infiltration in Lung Adenocarcinoma Lung adenocarcinoma (LUAD), a common subtype of non-small cell lung cancer (NSCLC), has a high incidence and mortality rate. Despite significant progress in early detection and treatment, the overall survival (OS) rate of LUAD patients re...

Multiomic Analysis Identifies Survival Predictors in African American Patients with Acute Myeloid Leukemia

Medicine, Medical Laboratory Science, Hematology, Oncology, Life Sciences, Cell Biology, Immunology, Genetics,
acute myeloid leukemia   African American   gene mutations   inflammation   survival predictors   genomic analysis   multiomic study  

Multi-omics Analysis Reveals Predictors of Survival in African American AML Patients Background and Objectives Acute Myeloid Leukemia (AML) is a hematologic malignancy characterized by clonal expansion of myeloid progenitor cells driven by genomic alterations. Despite advances in genomic profiling, studies focusing on diverse ancestral populations ...

Intravenous Administration of an AAV9 Vector Ubiquitously Expressing C1ORF194 Gene Improved CMT-like Neuropathy in C1ORF194-/- Mice

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
CMT disease   C1ORF194   gene therapy   AAV9   neuropathy   motor ability   sensory nerves  

Research Report on the Improvement of CMT-like Neuropathy via AAV9 Vector-based C1ORF194 Gene Therapy Background and Research Motivation Charcot-Marie-Tooth disease (CMT) is a rare group of genetically heterogeneous neuromuscular disorders characterized by progressive muscle weakness and atrophy, along with sensory loss. Despite extensive preclinic...

Population-wide DNA Methylation Polymorphisms at Single-Nucleotide Resolution in 207 Cotton Accessions Reveal Epigenomic Contributions to Complex Traits

Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics, Botany,
cotton   DNA methylation   gene expression   epigenetics   fiber quality  

Cotton Population-Level DNA Methylation Polymorphism Study Reveals Epigenomic Contributions to Complex Traits Background and Research Motivation In recent decades, genome and genetic diversity have been extensively studied through genome-wide association studies (GWAS), providing a theoretical foundation for understanding crop trait variations. How...