Epitope Editing Protects Hematopoietic Cells from CD123 Immunotherapy for Acute Myeloid Leukemia

Medicine, Hematology, Oncology, Life Sciences, Bioengineering, Immunology, Genetics,
epitope editing   CD123   immunotherapy   acute myeloid leukemia   hematopoietic stem cells   CAR-T  

Epitope Prime Editing Shields Hematopoietic Cells from CD123 Immunotherapy: A Novel Therapeutic Strategy for Acute Myeloid Leukemia Research Background and Problem Statement Acute Myeloid Leukemia (AML) is a malignant blood disease characterized by the abnormal differentiation of myeloid hematopoietic stem and progenitor cells (HSPCs). Its incidenc...

Modeling the Atrioventricular Conduction Axis using Human Pluripotent Stem Cell-Derived Cardiac Assembloids

Medicine, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Genetics,
atrioventricular conduction   cardiac assembloids   pluripotent stem cells   cardiomyocytes   electrophysiology  

Modeling the Atrioventricular Conduction Axis Based on Human Pluripotent Stem Cell-Derived Cardiac Assembloids Research Background The atrioventricular (AV) conduction axis is responsible for electrical conduction between the atrium and the ventricle and is a core component of the cardiac electrophysiological system. The delay function of AV conduc...

Alveolar Regeneration by Airway Secretory-Cell-Derived p63+ Progenitors

Medicine, Respiratory System, Life Sciences, Cell Biology, Biochemistry, Genetics,
alveolar regeneration   airway secretory cells   p63+ progenitors   genetic lineage tracing   lung injury  

Alveolar Regeneration: Role of p63+ Progenitor Cells Derived from Airway Secretory Cells Background Introduction Effective gas exchange in the lungs relies on the precise structure and function of various epithelial cells, distributed across two distinct structural regions: ductal airways and alveoli. When alveoli are damaged (e.g., due to inhaled ...

Marmoset and Human Trophoblast Stem Cells Differ in Signaling Requirements and Recapitulate Divergent Modes of Trophoblast Invasion

Life Sciences, Cell Biology, Biochemistry, Genetics,
marmoset   trophoblast stem cells   signaling   placental development   trophoblast invasion  

Differences in Signaling Requirements for Trophoblast Stem Cells between Humans and Marmosets Background and Research Motivation Embryo implantation and placenta formation are critical features of eutherian mammalian development. The trophoblast is a group of outer cells of the embryo that mediates the connection between the embryo and maternal tis...

Inflammation-Induced Epigenetic Imprinting Regulates Intestinal Stem Cells

Medicine, Gastroenterology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
Inflammation   Epigenetics   Intestinal stem cells   Metabolic changes   Regeneration capacity  

Inflammation-Induced Epigenetic Imprinting and Intestinal Stem Cell Regulation In recent years, the scientific community has shown immense interest in the “memory” capabilities of non-immune cells, particularly the phenomenon where specific stem cells in adult tissues develop memory after undergoing inflammation, influencing their functionality. Ho...

A Primate-Specific Endogenous Retroviral Envelope Protein Sequesters SFRP2 to Regulate Human Cardiomyocyte Development

Medicine, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Genetics,
endogenous retrovirus   cardiomyocytes   SFRP2   Wnt/β-catenin signaling   embryonic development  

A Primate-Specific Endogenous Retroviral Envelope Protein Regulates Human Cardiomyocyte Development by Inhibiting SFRP2 Research Background and Significance Endogenous Retroviruses (ERVs) are remnants of ancient viral infections that integrated into the host genome and were inherited through the germline to modern human genomes during evolution. Th...