Integrated Electrophysiological and Genomic Profiles of Single Cells Reveal Spiking Tumor Cells in Human Glioma

Medicine, Neurology, Oncology, Life Sciences, Cell Biology, Genetics,
Single-cell analysis   Glioma   Electrophysiology   Genomics   SCRAM algorithm  

Integration of Electrophysiological and Genomic Analysis Reveals Tumor Cells Capable of Generating Action Potentials in Human Gliomas Background and Research Objectives Gliomas are the most common malignant tumors in the central nervous system, with approximately 20,000 new cases annually. These tumors include two subtypes: isocitrate dehydrogenase...

Distinct Clinical Outcomes and Biological Features of Specific KRAS Mutants in Human Pancreatic Cancer

Medicine, Basic Medical Sciences, Oncology, Life Sciences, Biochemistry, Genetics,
KRAS   mutants   pancreatic cancer   early-stage   clinical outcomes  

Clinical Outcomes and Biological Characteristics Study Report for Pancreatic Cancer Patients with KRAS Mutations Research Background and Objective Pancreatic Ductal Adenocarcinoma (PDAC) is predicted to become the second leading cause of cancer death by 2030. Only about 20% of PDAC patients are eligible for resection surgery, thus the five-year sur...

GABAergic Neuronal Lineage Development Determines Clinically Actionable Targets in Diffuse Hemispheric Glioma

Medicine, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
GABAergic neurons   lineage development   diffuse hemispheric glioma   H3G34 mutation   CDK6   tumor therapy  

Background and Research Objectives High-Grade Glioma (HGG) is a highly lethal primary brain tumor with a particularly high incidence and mortality rate in children and adolescents. HGG can be further divided into several subtypes, among which Diffuse Hemispheric Glioma, H3G34-mutant (DHG-H3G34), is a rare subtype with poor prognosis, mainly occurri...

FUS/CircZEB1/miR-128-3p/LBH Feedback Loop Promotes Malignant Phenotype of GSCs via TNF-α Mediated NF-κB Signaling Pathway

Medicine, Neurology, Oncology, Life Sciences, Biochemistry, Immunology, Genetics,
Glioblastoma   CircZEB1   Glioma Stem Cells   Limb-Bud and Heart   NF-κB Signaling Pathway  

The Role of the Novel Circular RNA circZEB1 in the Malignant Phenotype of Glioblastoma Stem Cells and Its Molecular Mechanism Research Background Glioblastoma (GBM) is one of the most aggressive and fatal primary tumors in the central nervous system, with a very poor prognosis for patients. Even with surgery, radiotherapy, and chemotherapy, the ave...

Life History Dynamics of Evolving Tumors: Insights into Task Specialization, Trade-offs, and Tumor Heterogeneity

Medicine, Oncology, Life Sciences, Cell Biology, Immunology, Genetics,
tumor evolution   task specialization   heterogeneity   trade-offs   tumor microenvironment  

Cancer Cell International - Review Report Background and Motivation In recent decades, research into cancer evolution has gradually revealed that the evolutionary patterns of cancer cells share many similarities with species evolution. This notion has changed our understanding of tumor evolution and heterogeneity. Cancer is initiated by the mutatio...

Systematic Multiomics Analysis and In Vitro Experiments Suggest ITGA5 as a Promising Therapeutic Target for CCRCC

Medicine, Nephrology, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
ITGA5   multiomics analysis   clear cell renal cell carcinoma   tumor microenvironment   therapeutic target  

Systematic Multi-Omics Analysis and In Vitro Experiments Suggest ITGA5 as a Potential Target for Clear Cell Renal Cell Carcinoma (ccRCC) Treatment Research Background and Motivation Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma (RCC), accounting for about 75% of all kidney cancer cases. According to the ...