Towards Cascading Genetic Risk in Alzheimer’s Disease

Medicine, Geriatrics, Neurology, Neurosurgery, Life Sciences, Biochemistry, Genetics,
Alzheimer’s disease   APOE   polygenic risk   longitudinal progression   biomarker  

Cascading Pattern in Genetic Risk Research for Alzheimer’s Disease Background and Research Motivation Alzheimer’s disease (AD) is a slowly progressing neurodegenerative disorder characterized by the accumulation of two pathological features: amyloid plaques and phosphorylated tau neurofibrillary tangles. These pathological features typically exist ...

Biallelic Variants in SNUPN Cause a Limb Girdle Muscular Dystrophy with Myofibrillar-like Features

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Genetics,
SNUPN gene   small nuclear ribonucleoproteins   splicing   myopathy   limb girdle muscular dystrophy  

Biallelic Variants in SNUPN Cause a Limb-Girdle Muscular Dystrophy with Myofibrillar Features Academic Background Muscular dystrophies are a complex and heterogeneous group of neuromuscular disorders characterized by progressive muscle weakness and atrophy due to loss of muscle fibers. Limb-Girdle Muscular Dystrophies (LGMD) are a subtype primarily...

Transcriptome Dynamics and Cell Dialogs Between Oocytes and Granulosa Cells in Mouse Follicle Development

Medicine, Obstetrics and Gynecology, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
oocyte   granulosa cell   transcriptome   folliculogenesis   cell dialog  

Transcriptome Dynamics and Cell Dialogue Between Oocytes and Granulosa Cells During Mouse Follicle Development Overview Follicle development and maturation is a complex, multi-stage process. During this process, dynamic gene expression in oocytes and surrounding somatic cells, as well as the dialogue between them, play crucial roles. This study rev...

Integrated Single-Cell Multiomic Analysis Reveals Novel Regulators of HIV Latency Reversal

Medicine, Infectious Diseases, Life Sciences, Cell Biology, Genetics,
HIV latency reversal   primary CD4+ T cell   single-cell multiomics   HIV-regulating factor   machine learning  

Comprehensive Single-Cell Multi-Omics Study on HIV Latency Reversal Reveals Novel Regulators of Viral Reactivation This paper, titled “Integrated single-cell multiomic analysis of HIV latency reversal reveals novel regulators of viral reactivation,” was jointly completed by Manickam Ashokkumar, Wenwen Mei, and several other researchers from institu...

Whole-Genome Sequencing Reveals Autooctoploidy in Chinese Sturgeon and Its Evolutionary Trajectories

Life Sciences, Genetics, Microbiology,
Chinese sturgeon   whole-genome sequencing   autooctoploid   polyploidization   diploidization   whole-genome duplication  

Whole-Genome Sequencing Reveals Autopolyploidy and Evolutionary Trajectory of Chinese Sturgeon Background Chinese sturgeon (Acipenser sinensis), as a member of the sturgeon subclass, is an ancient fish group. Due to its unique genome structure and economic value, the conservation and research of Chinese sturgeon are of great significance. Sturgeons...

Benchmarking Algorithms for Gene Set Scoring of Single-Cell ATAC-Seq Data

Information Science, Computer Science, Artificial Intelligence, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
single-cell ATAC-Seq   gene set scoring   pathway analysis   single-cell RNA-Seq   benchmark  

Benchmarking Gene Set Scoring Tools for Single-Cell ATAC-seq Data Authors: Xi Wang, Qiwei Lian, Haoyu Dong, Shuo Xu, Yaru Su, Xiaohui Wu Affiliations: Pasteurien College (Soochow University Medical College), Department of Automation, Xiamen University, School of Mathematics and Computer Science, Fuzhou University Corresponding Author: xhwu@suda.edu...