A Telomere-to-Telomere Complete Diploid Genome Assembly for Han Chinese

Medicine, Basic Medical Sciences, Life Sciences, Biochemistry, Genetics,
reference genome   telomere-to-telomere   Han Chinese   haplotype-resolved assembly   diploid  

T2T-YAO: Assembly of a Han Chinese Full-length Diploid Reference Genome Scientific Background Since the launch of the Human Genome Project (HGP) thirty years ago, the field of biomedical research has set a long-term goal of constructing a complete and accurate human reference genome. However, due to limitations in sequencing technology, it has long...

Aging-induced tRNAglu-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
aging   tRNA-derived fragment   mitochondria   glutamate   cristae organization   memory decline  

Aging-induced trnaGlu-derived fragments disrupt glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization Academic Background Mitochondrial cristae are inward protrusions of the inner mitochondrial membrane that undergo significant morphological changes during aging. However, the molecular mechanisms leading to th...

A Human Omentum-Specific Mesothelial-Like Stromal Population Inhibits Adipogenesis Through IGFBP2 Secretion

Medicine, Endocrinology, Gastroenterology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
Omentum-Specific   Mesothelial-Like Cells   Stromal Cells   IGFBP2   Adipogenesis  

A Human Omentum-Specific Intermesothelial Fibroblast Population Inhibits Adipogenesis by Secreting IGFBP2 Background and Research Objective With the growing prevalence of obesity and metabolic diseases, the plasticity and heterogeneity of adipose tissue have become research hotspots. Different regions of adipose tissue exhibit distinct metabolic ch...

A novel protein cytb-187aa encoded by the mitochondrial gene cytb modulates mammalian early development

Medicine, Obstetrics and Gynecology, Life Sciences, Cell Biology, Biochemistry, Genetics,
mitochondria   cytb-187aa   early development   ATP production   pluripotent state   ovarian follicles   female fertility  

The New Protein Cytb-187aa Regulates Mammalian Early Development Academic Background Mitochondria are multifunctional organelles that provide energy for cells. In addition to energy supply, they are involved in the regulation of apoptosis, cell signaling, and various biosynthetic pathways. Among these functions, substances within mitochondria can b...

Clinical, Histopathologic, and Genetic Features of Patients with Myofibrillary and Distal Myopathies: Experience from the Italian Network

Medicine, Respiratory System, Neurology, Cardiovascular System, Life Sciences, Genetics,
Myofibrillary Myopathies   Distal Myopathies   Clinical Features   Histopathologic Features   Genetic Features   Italian Network   Molecular Confirmation  

Clinical, Histopathological, and Genetic Characterization: Insights from Myofibrillar and Distal Myopathies Patients in the Italian Network Background and Research Motivation Myofibrillar Myopathies (MFM) and Distal Myopathies (DM) are a group of rare diseases with complex pathological presentations. The diagnosis process is extremely complicated d...

Genetic Associations with an Amyotrophic Lateral Sclerosis Reversal Phenotype

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
Amyotrophic Lateral Sclerosis   Reversal Phenotype   Genome-Wide Association Study   Gene Expression   IGFBP7  

Genetic Association Study of ALS Reversal Phenotype Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the death of upper and lower motor neurons, progressive weakness, and eventual respiratory failure. However, individual ALS patients have exhibited unusual clinical reversal phenomena, where symptoms signific...