Genomics Yields Biological and Phenotypic Insights into Bipolar Disorder

Genomic Research on Bipolar Disorder Background Introduction Bipolar Disorder (BD) is a severe mental illness that significantly contributes to the global disease burden. Despite its high heritability (60-80%), the majority of its genetic basis remains unclear. Previous studies have primarily focused on European populations, with limited exploratio...

The Serotonergic Psychedelic DOI Impairs Deviance Detection in the Auditory Cortex

The Impairment of Deviance Detection in the Auditory Cortex by DOI Academic Background Psychedelics are a class of psychoactive substances that can significantly alter perception, cognition, and mood. In recent years, psychedelics have shown potential applications in treating conditions such as depression, anxiety, and trauma-related disorders. How...

Neuroimaging Meets Neurophysiology: Are There Cortical Somatotopic Motor Maps Outside of the Human Precentral Gyrus?

New Discoveries in Cortical Motor Maps Background Introduction Humans and other primates are capable of performing a wide range of complex body movements, the initiation and control of which rely on multiple cortical and subcortical structures. Among these, the primary motor cortex (M1), located in the precentral gyrus, is the core region for execu...

Research Priorities for Improving Cognitive and Neuropsychological Outcomes in Hydrocephalus

Research Priorities for Improving Cognitive and Neuropsychological Outcomes in Hydrocephalus Academic Background Hydrocephalus is a neurological disorder affecting approximately 85 per 100,000 individuals worldwide. It is closely associated with motor and cognitive impairments. Although advancements in surgical interventions have significantly impr...

Psychological Intervention for Caregivers of Patients with Primary Malignant Brain Tumors

Academic Background Caregivers of patients with Primary Malignant Brain Tumors (PMBT) face significant psychological distress. PMBT is not only an incurable cancer but also accompanied by degenerative neurological conditions, leading caregivers to cope with the gradual loss of the patient’s physical functions and irreversible changes in personality...