D1R-5-HT2AR Uncoupling Reduces Depressive Behaviors via HDAC Signaling

Medicine, Basic Medical Sciences, Psychiatry, Neurology, Clinical Psychology, Life Sciences, Cell Biology, Biochemistry, Immunology,
D1R   5-HT2AR   depression   HDAC   signaling   neurotransmitter   therapeutic strategies  

D1R-5-HT2AR Uncoupling Alleviates Depressive Behaviors Through HDAC Signaling Research Background Major depressive disorder (MDD) is a globally prevalent and life-threatening mental illness, closely associated with poor physical health. Despite the availability of various treatments, including medications and psychotherapy, many patients exhibit po...

A Brainstem Circuit Amplifies Aversion

Medicine, Neurology, Clinical Psychology, Life Sciences,
brainstem circuit   aversive value   fear learning   opioid withdrawal   GABA neurons  

A Mechanism of Brainstem Circuit Enhancing Aversion Response Background and Motivation Aversion response is a natural reaction in humans and animals when faced with threats or unpleasant stimuli, allowing individuals to avoid danger and playing a critical role in adaptation during evolution. However, excessive aversion can lead to a range of emotio...

Different Learning Aberrations Relate to Delusion-like Beliefs with Different Contents

Medicine, Basic Medical Sciences, Psychiatry, Neurology, Clinical Psychology,
Learning Aberrations   Delusions   Prediction Error   Psychiatric Disorders   Paranoia   Cognitive Tasks  

A Study on the Correlation Between Different Learning Abnormalities and Delusional-like Beliefs of Various Contents Research Background Delusions are a major feature of psychotic disorders (such as schizophrenia, bipolar disorder, depression, and certain neurological and autoimmune diseases). Although delusions clinically manifest as fixed erroneou...

Graded Multidimensional Clinical and Radiologic Variation in Patients with Alzheimer Disease and Posterior Cortical Atrophy

Medicine, Geriatrics, Neurology, Clinical Psychology, Medical Imaging,
Alzheimer Disease   Posterior Cortical Atrophy   Cognitive Impairments   Brain Volumes   Neuroimaging  

Research Report on Progressive Multidimensional Clinical and Radiological Variations in Patients with Alzheimer’s Disease and Posterior Cortical Atrophy Background Introduction Alzheimer’s Disease (AD) has multiple phenotypes, including the typical amnestic and non-amnestic (atypical) phenotypes. Posterior Cortical Atrophy (PCA) is a prominent atyp...

A Vaping Cessation Text Message Program for Adolescent E-Cigarette Users: A Randomized Clinical Trial

Medicine, Pediatrics, Environmental and Public Health, Psychiatry, Clinical Psychology,
adolescents   e-cigarettes   vaping cessation   text message program   randomized clinical trial   public health  

E-cigarette Cessation SMS Program: A Randomized Clinical Trial Study Targeting Adolescent E-cigarette Users Background In recent years, e-cigarettes have become the most widely used tobacco product among American adolescents. Statistics from 2023 show that over 2.1 million adolescents reported current use of e-cigarettes, including 10% of high scho...