Therapeutic Potential of Isoallolithocholic Acid in Methicillin-Resistant Staphylococcus aureus Peritoneal Infection Background Methicillin-resistant Staphylococcus aureus (MRSA), discovered in 1961, has become one of the most common antibiotic-resistant bacteria worldwide. MRSA infections can lead to fatal sepsis, pneumonia, and high rates of skin...

Study on the Combination of Cefiderocol and Tetracycline Analogues for Treating Carbapenem-Resistant Acinetobacter baumannii Academic Background Carbapenem-resistant Acinetobacter baumannii (CR-AB) is one of the major pathogens responsible for hospital-acquired infections, often leading to severe conditions such as ventilator-associated pneumonia, ...

New Hope for the Treatment of Non-Tuberculous Mycobacterial Diseases—Research on Acetohydroxyacid Synthase Inhibitors Academic Background Non-tuberculous mycobacteria (NTM) infections have become an important cause of pulmonary diseases worldwide in recent years, especially among immunocompromised populations. The treatment of NTM infections faces ...

Novobiocin Primarily Targets ParE in Neisseria gonorrhoeae Background Neisseria gonorrhoeae is a Gram-negative bacterium that causes gonorrhea, one of the most common sexually transmitted infections worldwide. According to the World Health Organization (WHO), there were 82.3 million new cases of gonorrhea among people aged 15–49 in 2020. However, t...

Structure-Function Analysis of 2-Sulfamoylacetic Acid Synthase in Altemicidin Biosynthesis Academic Background Sulfonamide antibiotics, such as altemicidin and its analogs, have garnered significant attention due to their notable antitumor and antibacterial activities. These compounds feature a rare sulfonamide side chain, which holds great importa...