Temporal and Spatial Regulation of Biomimetic Vascularization in 3D-Printed Skeletal Muscles

Temporal and Spatial Regulation of Biomimetic Vascularization in 3D-Printed Skeletal Muscles

Application of 3D Printing Technology in Skeletal Muscle Vascularization Research Academic Background Skeletal muscle tissue is one of the most important tissues in the human body, and its function relies on the close relationship between myotubes and the vascular network. The vascular network not only supplies oxygen and nutrients to skeletal musc...

Multisite DNA Methylation Alterations of Peripheral Blood Mononuclear Cells Serve as Novel Biomarkers for the Diagnosis of AIS/Stage I Lung Adenocarcinoma: A Multicenter Cohort Study

Novel Early Diagnosis Method for Lung Adenocarcinoma Based on DNA Methylation in Peripheral Blood Mononuclear Cells Background Lung adenocarcinoma (LUAD) is one of the leading causes of cancer-related deaths worldwide, accounting for approximately 40% of lung cancer cases. Despite significant advancements in treatment, the prognosis of LUAD remains...

Investigating the Validity of MCIM and SCIM Phenotypic Methods in Screening Pseudomonas aeruginosa Isolates Producing IMP, VIM, and NDM Metallo-Beta-Lactamases Isolated from Burn Wounds

Investigating the Validity of mCIM and sCIM Phenotypic Methods in Screening Pseudomonas aeruginosa Isolates Producing IMP, VIM, and NDM Metallo-β-Lactamases from Burn Wounds Background Pseudomonas aeruginosa is a Gram-negative bacterium widely found in the environment, particularly in hospital settings. It is the second most common pathogen causing...

Aztreonam-Avibactam: A New Combination with Activity Against Multidrug-Resistant Klebsiella pneumoniae Complex

Aztreonam-Avibactam Activity Against Multidrug-Resistant Klebsiella pneumoniae Complex Background The Klebsiella pneumoniae complex (KPC) is a group of opportunistic pathogens that pose a serious threat to public health. In recent years, the infection rate of multidrug-resistant (MDR) Klebsiella pneumoniae has significantly increased, leading to ex...

Cryptoic Acids A and B, Benzene-Containing Polyketides, and Cyclocryptamide, a Modified Diketopiperazine, from an Actinomycete of the Genus Cryptosporangium

Novel Benzene-Containing Polyketides and Modified Diketopiperazine from Actinomycete of the Genus Cryptosporangium Academic Background Microbial natural products hold significant value in drug development, particularly actinomycetes, which provide a rich source of various therapeutic compounds, such as aminoglycosides, macrolides, and tetracyclines...