Role of Macrophages in CL-Enhanced Regeneration After Peripheral Nerve Injury

Medicine, Neurology, Neurosurgery, Life Sciences, Cell Biology, Immunology,
Macrophages   Peripheral nerve regeneration   CL response   Neuroinflammation   CCR2  

Key Research on the Role of Macrophages in Peripheral Nerve Regeneration Background and Research Objectives Since the 1990s, research has shown that macrophages play a promoting role in peripheral nerve regeneration, and are particularly important in the conditioning lesion (CL) response. After sciatic nerve injury, macrophages accumulate at the in...

CCR5-overexpressing mesenchymal stem cells protect against experimental autoimmune uveitis: insights from single-cell transcriptome analysis

Medicine, Rheumatology and Immunology, Ophthalmology, Life Sciences, Cell Biology, Biochemistry, Immunology,
CCR5   mesenchymal stem cells   autoimmune uveitis   single-cell transcriptome analysis   ocular inflammation   systemic immune response  

Protective effects of CCR5-overexpressing mesenchymal stem cells on experimental autoimmune uveitis Background Introduction Uveitis is an inflammatory eye disease that seriously threatens vision and can lead to complications such as cataracts, glaucoma, vitreous opacities, retinal detachment, and abnormal retinal vasculature. This disease is widesp...

Microglial PDCD4 Deficiency Mitigates Neuroinflammation-Associated Depression via Facilitating Daxx Mediated PPARγ/IL-10 Signaling

Medicine, Infectious Diseases, Psychiatry, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Microglia   PDCD4   Neuroinflammation   Depression   PPARγ   IL-10  

Deletion of Microglia PDCD4 Alleviates Neuroinflammation-Associated Depression by Promoting DAXX-Mediated PPARγ/IL-10 Signaling Background In recent years, neuroinflammatory processes have been demonstrated to be associated with various psychiatric disorders, including schizophrenia, depression, and anxiety. A common feature of these diseases is th...

Single-Cell RNA Sequencing Reveals the Evolution of the Immune Landscape During Perihematomal Edema Progression After Intracerebral Hemorrhage

Medicine, Rheumatology and Immunology, Neurology, Hematology, Life Sciences, Cell Biology, Biochemistry, Immunology,
intracerebral hemorrhage   single cell RNA sequencing   perihematomal edema   immune cell   osteopontin  

Single-cell RNA Sequencing Reveals Evolution of Immune Landscape in Perihematomal Edema Post Hemorrhagic Stroke Research Background Intracerebral hemorrhage (ICH) is one of the global health threats, renowned for its high disability and mortality rates. Among the secondary brain injuries caused by ICH, the formation of perihematomal edema (PHE) is ...

Neonatal Respiratory Infection Causes Neuroinflammation in the Brainstem

Medicine, Infectious Diseases, Pediatrics, Neurology, Life Sciences, Cell Biology, Immunology, Microbiology,
medulla oblongata   cytokines   microglia   astrocytes   sex-specific   neonatal  

Neonatal Respiratory Infections Lead to Brainstem Neuroinflammation Introduction Respiratory infections are one of the most common diseases and causes of morbidity among newborns. During the acute phase, infections are known to cause widespread peripheral inflammation. However, the effect of this inflammation on the critical neural centers that con...

Impaired GABAergic Regulation and Developmental Immaturity in Interneurons Derived from the Medial Ganglionic Eminence in the Tuberous Sclerosis Complex

Medicine, Psychiatry, Neurology, Life Sciences, Cell Biology, Immunology,
GABAergic interneurons   snRNA-seq   ganglionic eminence   somatostatin   immaturity  

Hippocampal Neurons - The Destructive Force Behind Epilepsy and Mental Disorders Background Introduction Tuberous Sclerosis Complex (TSC) is a complex multi-system genetic disorder that manifests with lesions in the brain, skin, heart, kidneys, and other organs as the patient ages. Clinically, TSC presents with symptoms such as epilepsy and develop...