RNA Binding Protein with Multiple Splicing (RBPMS) Promotes Contractile Phenotype Splicing in Human Embryonic Stem Cell-Derived Vascular Smooth Muscle Cells

Medicine, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry,
RNA binding protein   vascular smooth muscle cells   splicing   embryonic stem cells   contractile phenotype  

The Critical Role of RNA-Binding Protein RBPMS in Vascular Smooth Muscle Cells Academic Background Vascular Smooth Muscle Cells (VSMCs) are the primary structural components of large arteries. In healthy blood vessels, VSMCs exhibit a mature contractile phenotype, responsible for regulating vascular tone and blood flow. However, VSMCs possess pheno...

SCICONE: Single-Cell Copy Number Calling and Event History Reconstruction

Information Science, Computer Science, Medicine, Oncology, Life Sciences, Cell Biology, Bioengineering, Genetics,
single-cell sequencing   copy number variation   tumor evolution   SCICONE model   low-depth sequencing  

During tumor development, copy number alterations (CNAs) are key drivers of tumor heterogeneity and evolution. Understanding these variations is crucial for developing personalized cancer diagnostics and therapies. Single-cell sequencing technology offers the highest resolution for copy number analysis, down to the individual cell level. However, l...

Sul-BERTGRU: An Ensemble Deep Learning Method Integrating Information Entropy-Enhanced BERT and Directional Multi-GRU for S-Sulfhydration Sites Prediction

Information Science, Artificial Intelligence, Life Sciences, Cell Biology, Biochemistry,
deep learning   S-sulfhydration sites   information entropy   BERT   multi-directional GRU   protein modification   bioinformatics  

Background Introduction Post-Translational Modifications (PTMs) are crucial mechanisms for regulating cellular activities, including gene transcription, DNA repair, and protein interactions. Among these, cysteine, a rare amino acid, participates in various PTMs through its thiol group, playing a significant role in redox balance and signal transduc...

Single-Cell Unified Polarization Assessment of Immune Cells

Information Science, Computer Science, Life Sciences, Cell Biology, Immunology,
single-cell RNA sequencing   immune cell polarization   cytokine-driven   computational method   tumor infiltration   transcriptome   cell embeddings  

Immune cells undergo cytokine-driven polarization in response to various stimuli, which alters their transcriptional profiles and functional states. This dynamic process plays a central role in immune responses in both health and disease. However, there has been a lack of systematic methods to assess cytokine-driven polarization in single-cell RNA ...

Trajectory Alignment of Gene Expression Dynamics

Medicine, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology, Genetics, Microbiology,
gene expression   single-cell transcriptomics   trajectory alignment   bioinformatics   differentially expressed genes  

The advent of single-cell RNA sequencing (scRNA-seq) technology has provided unprecedented resolution for studying gene expression dynamics during cell development and differentiation. However, due to the complexity of biological processes, cell developmental trajectories under different conditions are often asymmetric, posing challenges for data i...

Inhibiting Cell Inspection Points Intervention via Injectable Short Fibers for Reversing Neural Cell Senescence

Medicine, Neurology, Neurosurgery, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
neural cell senescence   inspection point   short fibers   spinal cord   genome homeostasis  

Background Introduction Spinal Cord Injury (SCI) is a significant challenge in the medical field, particularly in terms of neural function recovery. Research indicates that neurons play a crucial role in spinal cord regeneration, but in complex pathological environments, neurons are influenced by various factors, leading to rapid senescence. Senesc...