Background Introduction Spinal Cord Injury (SCI) is a significant challenge in the medical field, particularly in terms of neural function recovery. Research indicates that neurons play a crucial role in spinal cord regeneration, but in complex pathological environments, neurons are influenced by various factors, leading to rapid senescence. Senesc...
Academic Background During tissue repair, chronic hypoxia negatively impacts the functionality of stem cells. Periosteal Stem Cells (PSCs), as the primary contributors to bone repair, exhibit unclear behavior under hypoxic conditions. While hypoxia may be beneficial for certain stem cells in the early stages of tissue repair, prolonged hypoxia can ...
Academic Background The regenerative capacity of the nervous system varies significantly between different regions. Axons in the peripheral nervous system (PNS) can regenerate spontaneously after injury, whereas axons in the central nervous system (CNS) lack this ability. This difference makes recovery after CNS injury extremely challenging, especi...
S-nitrosylation of CRTC1 in Alzheimer’s Disease Impairs CREB-dependent Gene Expression Induced by Neuronal Activity Academic Background Alzheimer’s disease (AD) is a common neurodegenerative disorder characterized by the gradual loss of memory and cognitive function. The pathological mechanisms of AD are complex, involving various molecular and cel...
Radiation-Induced Cellular Plasticity Primes Glioblastoma for Forskolin-Mediated Differentiation Academic Background Glioblastoma (GBM) is one of the deadliest brain cancers in adults, with a median survival period of only 15 to 18 months for patients. Although surgery combined with chemoradiotherapy can delay disease progression, these treatments ...
Endocannabinoids Released on Demand via Extracellular Microvesicles Academic Background Endocannabinoids (ECBs) are a class of lipid neurotransmitters that play a critical role in brain function by activating cannabinoid receptor CB1. Unlike classical neurotransmitters, the storage and release mechanisms of ECBs have remained elusive, leading to si...