CDC42 is crucial for the early regulation of hepatic stellate cell activation

Medicine, Hepatobiliary System, Gastroenterology, Life Sciences, Cell Biology, Biochemistry, Immunology,
hepatic stellate cells   liver fibrosis   morphological alterations   CDC42   cell cycle  

CDC42 Plays a Crucial Role in the Early Regulation of Hepatic Stellate Cell Activation Academic Background Liver fibrosis is a pathological process associated with various liver diseases, which may eventually progress to cirrhosis—a life-threatening condition. Currently, there are no effective treatments to halt the progression of liver fibrosis. H...

Transmission of Peripheral Blood α-Synuclein Fibrils Exacerbates Synucleinopathy and Neurodegeneration in Parkinson’s Disease by Endothelial LAG3 Endocytosis

Medicine, Neurology, Life Sciences, Cell Biology, Immunology,
α-synuclein fibrils   Parkinson’s disease   LAG3 endocytosis   peripheral blood transmission   neurodegeneration  

Transmission of Peripheral Blood α-Synuclein Fibrils Exacerbates Synucleinopathy and Neurodegeneration in Parkinson’s Disease via Endothelial LAG3 Endocytosis Academic Background Parkinson’s disease (PD) is an age-related neurodegenerative disorder characterized by the abnormal formation and transmission of α-synuclein (α-syn). Recent studies have ...

Modeling Ocular Surface Ion and Water Transport by Generation of Lipid- and Mucin-Producing Human Meibomian Gland and Conjunctival Epithelial Cells

Medicine, Ophthalmology, Life Sciences, Cell Biology, Biochemistry, Biophysics,
Meibomian gland   conjunctival epithelial cells   ion channels   aquaporin   tear secretion  

Modeling of Ion and Water Transport on the Human Ocular Surface Background Introduction The ocular surface plays a crucial role in human physiology and diseases, especially the stability and composition of the tear film, which directly impact ocular surface health. The tear film consists of three layers: an outer lipid layer (secreted by the meibom...

Senescent Myoblasts Exhibit an Altered Exometabolome Linked to Senescence-Associated Secretory Phenotype Signaling

Medicine, Geriatrics, Life Sciences, Cell Biology, Biochemistry, Immunology,
senescence   myoblasts   metabolome   SASP signaling   monounsaturated fatty acids  

Research Report on Changes in the Metabolome of Senescent Myoblasts Research Background As age increases, the function of skeletal muscle gradually deteriorates, a phenomenon closely related to the senescence of muscle stem cells (satellite cells). Satellite cells play a key role in muscle injury repair. However, during the aging process, the funct...

Sulforaphane Treatment Mimics Contractile Activity-Induced Mitochondrial Adaptations in Muscle Myotubes

Medicine, Sports Medicine, Life Sciences, Cell Biology, Biochemistry,
Sulforaphane   Mitochondrial Biogenesis   Nrf-2   PGC-1α   Skeletal Muscle  

Sulforaphane Mimics Contractile Activity-Induced Mitochondrial Adaptations in Muscle Research Background Mitochondria are central regulators of skeletal muscle health, acting as the cell’s power plants. The function and quality of mitochondria directly impact muscle health. Exercise has been widely proven to be an effective means of enhancing mitoc...

RFC4 Confers Radioresistance of Esophagus Squamous Cell Carcinoma through Regulating DNA Damage Response

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
RFC4   esophageal squamous cell carcinoma   radioresistance   DNA damage repair   p53 signaling pathway  

New Discovery in the Mechanism of Radioresistance in Esophageal Squamous Cell Carcinoma: The Role of the RFC4 Gene Academic Background Esophageal squamous cell carcinoma (ESCC) is one of the most common gastrointestinal malignancies in China, and radiotherapy is a crucial treatment modality. However, radioresistance in tumor cells is a major cause ...