Academic Background Scar formation is a common issue following trauma, burns, and other complications, significantly impacting the quality of life for millions of people worldwide. Fibroblasts play a central role in pathological scar formation, making them a common target for developing new therapies to promote healing and reduce scarring. Recent s...
Vaginal wound healing is a critical issue in gynecological surgery, especially following vaginal delivery or pelvic reconstructive surgery. Infection and poor healing of vaginal wounds can lead to severe complications such as chronic pain, infection, and dysfunction. Therefore, accelerating vaginal wound healing has been a focal point of clinical r...
Background Introduction Single-cell RNA sequencing (scRNA-seq) technology has been widely applied in biomedical research in recent years, as it can reveal the heterogeneity of gene expression at the single-cell level, providing an important tool for understanding cell types, cell states, and disease mechanisms. However, scRNA-seq data is characteri...
Background Introduction Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide, with high incidence and mortality rates. According to statistics, approximately 1.87 million new cases of CRC were diagnosed globally in 2020, resulting in 915,000 deaths. Peritoneal metastasis (PM) is a common metastatic pathway of CRC, with about ...
Academic Background Introduction The spliceosome is a highly dynamic macromolecular complex responsible for the precise excision of introns from pre-mRNA. Although recent advances in cryo-electron microscopy (cryo-EM) have provided a comprehensive structural understanding of the stepwise assembly, catalytic splicing, and final disassembly of the sp...
Academic Background Equilibrioception is a crucial ability for mammals to perceive and navigate the three-dimensional world. This ability relies on the rapid mechanoelectrical transduction (MET) response of vestibular hair cells (VHCs), which detects the position and motion of the head. Although previous studies have shown that transmembrane channe...