The Endocannabinoid 2-Arachidonoylglycerol is Released and Transported on Demand via Extracellular Microvesicles

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Biophysics,
endocannabinoid   2-arachidonoylglycerol   extracellular microvesicles   on-demand release   neurotransmission   cannabinoid receptor   neuron  

Endocannabinoids Released on Demand via Extracellular Microvesicles Academic Background Endocannabinoids (ECBs) are a class of lipid neurotransmitters that play a critical role in brain function by activating cannabinoid receptor CB1. Unlike classical neurotransmitters, the storage and release mechanisms of ECBs have remained elusive, leading to si...

GABAergic synapses between auditory efferent neurons and type II spiral ganglion afferent neurons in the mouse cochlea

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Biophysics,
cochlea   auditory efferent neurons   type II spiral ganglion afferent neurons   GABAergic synapses   mouse  

GABAergic Synapses Between Auditory Efferent Neurons and Type II Spiral Ganglion Afferent Neurons in the Mouse Cochlea Background Introduction The complexity and precision of the auditory system have always been important topics in neuroscience research. As a key component of the auditory system, the interactions between cells and neurons within th...

A Hormone-to-Neuropeptide Pathway Inhibits Sexual Receptivity in Immature Drosophila Females

Medicine, Endocrinology, Neurology, Life Sciences, Cell Biology, Genetics,
sexual transition   female receptivity   neuropeptide   ecdysone   Drosophila  

Study on Hormone-Neuropeptide Pathway Inhibiting Sexual Receptivity in Immature Drosophila Females Academic Background Sexual maturation is a critical developmental event in the transition from juvenile to adult, accompanied by multiple physiological and behavioral changes. In Drosophila, the process of transition from an asexual state to sexual ma...

Notch, ERK, and SHH Signaling Respectively Control the Fate Determination of Cortical Glia and Olfactory Bulb Interneurons

Medicine, Neurology, Neurosurgery, Life Sciences, Cell Biology,
cortical gliogenesis   Notch signaling   ERK signaling   SHH signaling   EGFR  

The Role of Notch, ERK, and SHH Signaling Pathways in the Fate Determination of Cortical Glial Cells and Olfactory Bulb Interneurons Academic Background During cortical development, neurogenesis and gliogenesis are two closely connected stages. Neurogenesis primarily generates neurons, while gliogenesis produces glial cells, including astrocytes an...

PTDP-43 Levels Correlate with Cell Type–Specific Molecular Alterations in the Prefrontal Cortex of C9orf72 ALS/FTD Patients

Medicine, Neurology, Life Sciences, Cell Biology, Immunology, Genetics,
neurodegenerative disorders   PTDP-43   C9orf72   prefrontal cortex   single-nucleus multiome analysis  

Correlation between PTDP-43 Levels and Cell-Specific Molecular Alterations in the Prefrontal Cortex of C9orf72 ALS/FTD Patients Background Introduction Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are two types of progressive neurodegenerative diseases. Their common feature is the loss of specific neuronal populations in th...

CDC42 is crucial for the early regulation of hepatic stellate cell activation

Medicine, Hepatobiliary System, Gastroenterology, Life Sciences, Cell Biology, Biochemistry, Immunology,
hepatic stellate cells   liver fibrosis   morphological alterations   CDC42   cell cycle  

CDC42 Plays a Crucial Role in the Early Regulation of Hepatic Stellate Cell Activation Academic Background Liver fibrosis is a pathological process associated with various liver diseases, which may eventually progress to cirrhosis—a life-threatening condition. Currently, there are no effective treatments to halt the progression of liver fibrosis. H...