Spatial Multiomic Landscape of the Human Placenta at Molecular Resolution

Medicine, Obstetrics and Gynecology, Life Sciences, Cell Biology, Biochemistry, Immunology,
placenta   multiomics   molecular resolution   gene regulation   pregnancy complications  

A New Chapter in the Molecular Understanding of the Human Placenta: Breakthroughs in Spatial Multiomics Background and Research Questions The placenta is the first fetal organ to develop during human pregnancy and plays a critical role in ensuring successful gestation and healthy fetal development. Despite its importance, our understanding of the m...

Gene-Level Alignment of Single-Cell Trajectories

Medicine, Life Sciences, Cell Biology, Immunology, Genetics,
single-cell RNA sequencing   pseudotime trajectory inference   dynamic time warping   gene expression   cell state  

Gene-level Single-cell Trajectory Alignment: A New Method Based on Dynamic Programming The advent of single-cell RNA sequencing (scRNA-seq) technology has dramatically advanced biological research, enabling scientists to observe dynamic changes at the single-cell level over time and space. However, comparing such dynamics across samples or conditio...

An Organotypic Atlas of Human Vascular Cells

Medicine, Cardiovascular System, Life Sciences, Cell Biology, Immunology,
vascular cells   single-cell transcriptomics   endothelial cells   mural cells   organotypic   molecular signatures   vascular diseases  

Decoding the Human Vascular System: A Comprehensive Multi-organ Single-cell Transcriptomic Study Reveals Vascular Cell Diversity Background Overview The human vascular system is a core component for sustaining life, comprising endothelial cells (ECs) and mural cells that span across all organ systems. Its functions extend beyond merely delivering b...

A Temporal Cortex Cell Atlas Highlights Gene Expression Dynamics During Human Brain Maturation

Medicine, Neurology, Life Sciences, Cell Biology, Genetics,
temporal cortex   single-nucleus RNA sequencing   brain maturation   gene expression   cell subtypes   cognition   synaptic plasticity  

Gene Expression Dynamics During Human Brain Maturation: A Novel Temporal Cortex Cell Atlas Academic Background The development and maturation of the human brain are critical areas in neuroscience, though many mysteries remain unresolved. Guided by changes in gene expression, the human brain undergoes a prolonged and complex postnatal maturation pro...

Efficient and Highly Amplified Imaging of Nucleic Acid Targets in Cellular and Histopathological Samples with PSABER

Medicine, Life Sciences, Cell Biology, Biochemistry, Genetics,
nucleic acid imaging   signal amplification   in situ hybridization   fluorescence microscopy   histopathology  

A New Platform for Efficient Signal Amplification of Nucleic Acid Targets in Tissue and Clinical Research: PSABER Background and Related Knowledge Since its first introduction by Pardue and Gall in the 1960s, in situ hybridization (ISH) has been widely adopted in research and clinical applications for its ability to spatially map nucleic acid targe...

The Maternal X Chromosome Affects Cognition and Brain Ageing in Female Mice

Medicine, Neurology, Life Sciences, Cell Biology, Genetics,
maternal X chromosome   cognitive function   brain ageing   female mice   genomic imprinting   hippocampus   CRISPR  

The Impact of the Maternal X Chromosome on Cognition and Brain Aging in Female Mice Background Introduction In mammals, female cells possess two X chromosomes, one from the mother (maternal X chromosome, Xm) and one from the father (paternal X chromosome, Xp). During embryonic development, one of the X chromosomes is randomly inactivated, a process...