Predicting Outcomes in Esophageal Squamous Cell Carcinoma Using scRNA-seq and Bulk RNA-seq: A Model Development and Validation Study

Medicine, Oncology, Life Sciences, Cell Biology, Immunology,
Esophageal squamous cell carcinoma   Glucose metabolism   Immune infiltration   Prognosis   Single-cell RNA sequencing   Bulk RNA sequencing   Bioinformatics  

Prognostic Prediction Model for Esophageal Squamous Cell Carcinoma Based on Single-Cell RNA Sequencing and Bulk RNA Sequencing Research Background Esophageal Squamous Cell Carcinoma (ESCC) is one of the most common malignant tumors globally, particularly prevalent in East Asia. Despite existing treatment methods such as surgery, endoscopic resectio...

Basal Ganglia and Related Disorders: From Cellular and Circuit Dysfunctions to Therapy

Medicine, Neurology, Life Sciences, Cell Biology,
Basal Ganglia   A2A Receptor   CB1 Receptor   GABA   Glutamate   Neuromodulation   Striatum  

The Interaction Between A2A Receptor and CB1 Receptor in GABA and Glutamate Release in the Basal Ganglia Background The basal ganglia are key structures in the brain responsible for motor control and reward-based behaviors. They receive excitatory inputs from the cortex and thalamus, with 80% of the synapses being glutamatergic, while the second mo...

Similar Deficiencies, Different Outcomes: Succinate Dehydrogenase Loss in Adrenal Medulla vs. Fibroblast Cell Culture Models of Paraganglioma

Medicine, Endocrinology, Oncology, Life Sciences, Cell Biology, Biochemistry,
Succinate Dehydrogenase   Paraganglioma   Adrenal Medulla   Fibroblasts   Metabolism   Tumorigenesis   Hypoxic Signaling  

Different Manifestations of SDH Loss in Adrenal Medulla vs. Fibroblast Models Background Introduction Succinate dehydrogenase (SDH) is a key enzyme in the mitochondrial tricarboxylic acid (TCA) cycle and electron transport chain, responsible for oxidizing succinate to fumarate and participating in electron transfer. SDH consists of four subunits (S...

PFKFB3-Dependent Redox Homeostasis and DNA Repair Support Cell Survival Under EGFR-TKIs in Non-Small Cell Lung Carcinoma

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry,
Non-small cell lung carcinoma   EGFR   PFKFB3   Oxidative stress   DNA repair   ROS-dependent cell death   Metabolic rewiring  

The Role of PFKFB3 in EGFR-TKIs Tolerance in Non-Small Cell Lung Cancer Background Introduction Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-related deaths worldwide. Epidermal growth factor receptor (EGFR) mutations are relatively common in NSCLC, accounting for approximately 15-30% of cases. Although EGFR tyrosine kin...

GCN2-SLC7A11 Axis Coordinates Autophagy, Cell Cycle, and Apoptosis and Regulates Cell Growth in Retinoblastoma upon Arginine Deprivation

Medicine, Ophthalmology, Oncology, Life Sciences, Cell Biology, Biochemistry,
GCN2   SLC7A11   retinoblastoma   arginine deprivation   autophagy   cell cycle   apoptosis  

GCN2-SLC7A11 Axis Regulates Cell Growth and Survival in Retinoblastoma Under Arginine Deprivation Background Retinoblastoma (RB) is a common intraocular malignant tumor in children, accounting for 4% of all childhood cancers. Although current treatments such as chemotherapy are effective in some patients, they have drawbacks such as multidrug resis...

Multimodal Imaging Unveils the Impact of Nanotopography on Cellular Metabolic Activities

Chemistry, Nanoscience, Materials Science, Medicine, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
nanotopography   nanopillar   cell metabolism   metabolic dynamics   multimodal imaging   multivariate analysis   unsupervised clustering  

The Impact of Nanotopography on Cellular Metabolic Activities: Multimodal Imaging Reveals New Insights Academic Background In the field of biomedicine, the interaction between cells and material surfaces is crucial for studying cell behavior, tissue engineering, and regenerative medicine. Nanoscale surface topography (nanotopography) has been shown...