The Role of Sirtuins in Obesity and Osteoporosis and Their Therapeutic Potential Academic Background Obesity and osteoporosis (OP) are increasingly severe public health issues worldwide. Obesity is not only closely related to metabolic diseases such as cardiovascular diseases and diabetes but also has a complex association with the occurrence of os...
The Critical Role of Calcium in Skeletal Muscle Function and Its Interaction with Mitochondria and the Endoplasmic Reticulum Academic Background Calcium ions (Ca²⁺) are crucial intracellular signaling molecules, particularly in the excitation-contraction coupling (ECC) of skeletal muscle. The contraction of skeletal muscle relies on the release and...
POLDIP2 Regulates Cerebral Vascular Permeability by Modulating ROS-Mediated ZO-1 Phosphorylation and Localization Background The blood-brain barrier (BBB) is a critical component of the central nervous system (CNS), composed of brain endothelial cells, astrocytes, pericytes, and neurons. Brain endothelial cells form a continuous physical barrier th...
N88S Seipin-related Seipinopathy is a Lipidopathy Associated with Loss of Iron Homeostasis Academic Background Seipin is a protein encoded by the human BSCL2 gene and the yeast SEI1 gene, forming an endoplasmic reticulum (ER)-bound homo-oligomer. This oligomer plays a crucial role in targeting ER-lipid droplet (LD) contact sites, facilitating the d...
PRDX5 and PRDX6 in Oxidative Stress Response During Cryopreservation of Bull Sperm Academic Background Cryopreservation is a critical step in animal breeding and assisted reproductive technologies, particularly in the preservation of bull sperm. However, oxidative stress generated during cryopreservation significantly reduces sperm quality, leading...
FOXC1-Mediated Serine Metabolism Reprogramming Enhances Colorectal Cancer Growth and 5-FU Resistance Background Colorectal cancer (CRC) is the third most common cancer globally and the second leading cause of cancer-related deaths. Although surgical resection and adjuvant chemotherapy are the primary treatments for CRC, tumor development and chemot...