Mapping the Gene Space at Single-Cell Resolution with Gene Signal Pattern Analysis

Life Sciences, Cell Biology, Bioengineering, Genetics,
single-cell sequencing   gene embedding   graph signal processing   bioinformatics   gene co-expression  

Mapping the Gene Space at Single-Cell Resolution: A Study on Gene Signal Pattern Analysis (GSPA) Academic Background Single-cell RNA sequencing (scRNA-seq) technology has made significant progress in biological research in recent years, particularly in revealing the organizational structure of the cellular state space. However, although many comput...

Spatial Modeling Algorithms for Reactions and Transport in Biological Cells

Life Sciences, Cell Biology, Biochemistry, Bioengineering, Biophysics,
spatial modeling   reaction-transport   cell signaling networks   subcellular structures   finite element analysis   computational biology   membrane reactions  

Research on Spatial Modeling Algorithms for Cellular Signaling Reactions and Transport Background Biological cells achieve their functions through complex biochemical reaction networks. These networks exhibit significant spatiotemporal dynamics, with pronounced spatial compartmentalization across different regions and subcellular structures. Howeve...

Efficacy and Cellular Mechanism of Biomimetic Marine Adhesive Protein-Based Coating Against Skin Photoaging

Chemistry, Nanoscience, Polymer Chemistry, Medicinal Chemistry, Materials Chemistry, Medicine, Medical Laboratory Science, Life Sciences, Cell Biology,
biomimetic   marine adhesive protein   skin photoaging   antioxidant   tissue repair   wet adhesion   protective coating  

Research Advances on the Use of Biomimetic Marine Adhesive Protein Coating for Skin Photoaging Prevention Skin photoaging is a significant global health issue, particularly for individuals exposed to prolonged ultraviolet (UV) radiation in outdoor environments. Its manifestations include a reduction in collagen, increased wrinkles, loss of skin ela...

Next-Generation Oral Ulcer Management: Integrating Cold Atmospheric Plasma (CAP) with Nanogel-Based Pharmaceuticals for Inflammation Regulation

Chemistry, Nanoscience, Medicinal Chemistry, Medicine, Basic Medical Sciences, Oral Sciences, Life Sciences, Cell Biology, Immunology,
Cold Atmospheric Plasma   Oral Ulcers   Nanogel   Inflammation Regulation   Epidermal Growth Factor Receptor   Biocompatibility   Therapeutic Enhancement  

Breakthrough in Next-Generation Oral Ulcer Management: Integration of Cold Plasma and Nanogel Pharmaceutical Systems Background Oral ulcers are one of the most common mucosal diseases, significantly affecting patients’ quality of life. According to epidemiological data, approximately 27.9% of adults suffer from oral ulcers. While these lesions ofte...

Bioprinted Micro-Clots for Kinetic Analysis of Endothelial Cell-Mediated Fibrinolysis

Medicine, Medical Laboratory Science, Hematology, Pharmacy, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology, Biophysics,
bioprinting   micro-clots   fibrinolysis   endothelial cells   venous thromboembolism   drug testing   high-throughput analysis  

Breakthrough Research on Micro-Scale Exploration of Thrombolysis Kinetics Research Background and Problem Venous thromboembolism (VTE), a severe health condition, causes approximately 500,000 deaths annually in the United States alone. The occurrence of VTE is closely related to the formation and resistance to dissolution of thrombi in veins, commo...

Incorporating Bone-Derived ECM into Macroporous Microribbon Scaffolds to Accelerate Bone Regeneration

Medicine, Orthopedics, Life Sciences, Cell Biology, Bioengineering, Immunology,
bone regeneration   macroporous scaffolds   extracellular matrix   tissue engineering   immunomodulation  

Incorporating Bone-Derived Extracellular Matrix (Bone-Derived ECM) into Macroporous Microribbon Scaffolds Accelerates Bone Regeneration Research Report With the continuous progress in the biomedical field, the application of tissue engineering and regenerative medicine in various tissue repairs has become increasingly important. However, research o...