Metabolic Profiling Reveals Nucleotide Synthesis as a Metabolic Vulnerability in Malignant Rhabdoid Tumors

Medicine, Pediatrics, Medical Laboratory Science, Oncology, Life Sciences, Cell Biology, Biochemistry,
malignant rhabdoid tumors   kidney cancer   nucleotide synthesis   metabolic vulnerability   patient-derived organoids   metabolic reprogramming   therapeutics  

Tumor Metabolic Reprogramming Identifies Key Vulnerability in Pediatric Malignant Tumors – Comprehensive Research Based on Organoid Models Background Malignant Rhabdoid Tumors (MRT) are highly invasive pediatric cancers that primarily affect infants and can develop throughout the body, with the intracranial variant known as Atypical Teratoid/Rhabdo...

Mechanism of Enhancing Chemotherapy Efficacy in Pancreatic Ductal Adenocarcinoma

Medicine, Gastroenterology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
pancreatic ductal adenocarcinoma   chemotherapy efficacy   paricalcitol   hydroxychloroquine   autophagy   tumor microenvironment   immune activation  

Research Report on Enhancing Chemotherapy Efficacy in Pancreatic Ductal Adenocarcinoma with Paricalcitol and Hydroxychloroquine Background Pancreatic Ductal Adenocarcinoma (PDAC) has an extremely low survival rate, with a 5-year survival rate of less than 15%. The primary reasons are early tumor metastasis and high resistance to chemotherapy and ra...

Coupling of Response Biomarkers Between Tumor and Peripheral Blood in Chemoimmunotherapy

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
biomarkers   chemoimmunotherapy   peripheral blood   tumor microenvironment   CD8+ T effector memory cells   immune prediction   malignant pleural mesothelioma  

Background Introduction This study focuses on malignant pleural mesothelioma (MPM), a rare and highly lethal cancer strongly associated with asbestos exposure. Most patients are diagnosed at advanced stages, with a survival time of only 12 to 15 months, and traditional treatments revolve around platinum-based chemotherapy. However, treatment paradi...

Role of Radiotherapy-Induced TREM1+ Mono-Macrophages in Rectal Cancer

Medicine, Rheumatology and Immunology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
radiotherapy   TREM1+   rectal cancer   monocytes   immunotherapy   antitumor immunity   biomarkers  

Phenotypic Plasticity of TREM1+ Mono-Macrophages Mediated by Radiotherapy Combined with Immunochemotherapy in Locally Advanced Rectal Cancer: A Comprehensive Multi-Omics Study Background Introduction Rectal cancer is the second leading cause of cancer-related deaths worldwide, accounting for one-third of all colorectal cancer cases. While surgical ...

Spatial Covariance Reveals Isothiocyanate Natural Products Adjust Redox Stress to Restore Function in Alpha-1-Antitrypsin Deficiency

Medicine, Hepatobiliary System, Respiratory System, Pharmacy, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
spatial covariance   isothiocyanate   redox stress   alpha-1-antitrypsin deficiency   natural products   protein folding   nutraceuticals  

Potential Therapeutic Role of Dietary Isothiocyanate Compounds in Alpha-1 Antitrypsin Deficiency (AATD) Background and Significance of the Study Alpha-1 Antitrypsin Deficiency (AATD) is a congenital, monogenic disease primarily caused by the misfolding of alpha-1 antitrypsin (AAT) in the liver. This misfolding leads to two pathological effects: the...

Single-cell analysis of cerebrospinal fluid reveals common features of neuroinflammation

Medicine, Infectious Diseases, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
single-cell analysis   neuroinflammation   cerebrospinal fluid   gene expression   immune cells   multiple sclerosis   lymphocyte clonal expansion  

Single-Cell Analysis Reveals Common Features of Neuroinflammation in Cerebrospinal Fluid Neuroinflammation is a core pathological feature of neurological diseases, involving complex interactions between the cerebrospinal fluid (CSF) and the peripheral immune system. Although previous studies have revealed the clonal expansion of lymphocytes in the ...