Incorporating Bone-Derived ECM into Macroporous Microribbon Scaffolds to Accelerate Bone Regeneration

Medicine, Orthopedics, Life Sciences, Cell Biology, Bioengineering, Immunology,
bone regeneration   macroporous scaffolds   extracellular matrix   tissue engineering   immunomodulation  

Incorporating Bone-Derived Extracellular Matrix (Bone-Derived ECM) into Macroporous Microribbon Scaffolds Accelerates Bone Regeneration Research Report With the continuous progress in the biomedical field, the application of tissue engineering and regenerative medicine in various tissue repairs has become increasingly important. However, research o...

Bioprinting Perfusable and Vascularized Skeletal Muscle Flaps for the Treatment of Volumetric Muscle Loss

Medicine, Basic Medical Sciences, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology,
bioprinting   vascularization   skeletal muscle flaps   volumetric muscle loss   tissue engineering   perfusion   transplantation  

Academic Report on “Bioprinting Perfusable and Vascularized Skeletal Muscle Flaps for the Treatment of Volumetric Muscle Loss” Background Muscle tissues constitute a significant portion of human cellular mass and are a complex, highly vascularized, and dynamic tissue. However, traumatic or surgical Volumetric Muscle Loss (VML)—defined as the loss o...

Mitochondria-Targeting Bimetallic Cluster Nanozymes Alleviate Neuropathic Pain through Scavenging ROS and Reducing Inflammation

Chemistry, Nanoscience, Medicinal Chemistry, Medicine, Neurology, Life Sciences, Cell Biology, Immunology,
mitochondria   anti-inflammation   neuropathic pain   reactive oxygen species   bimetallic nanozymes   oxidative stress   signaling pathways  

Mitochondria-Targeting Bimetallic Cluster Nanozymes Alleviate Neuropathic Pain by Scavenging ROS and Reducing Inflammation Background Introduction Neuropathic pain is a complex and multifaceted public health issue, with its high incidence and significant negative impact on patients’ quality of life making it a critical area of medical research. Cur...

Hormone Therapy Enhances Anti-PD1 Efficacy in Premenopausal Estrogen Receptor-Positive and HER2-Negative Advanced Breast Cancer

Medicine, Rheumatology and Immunology, Endocrinology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
hormone therapy   anti-PD1 antibody   estrogen receptor-positive breast cancer   HER2-negative   immune microenvironment   tumor immunotherapy  

Hormone Therapy Enhances Anti-PD-1 Efficacy: A Breakthrough Study Targeting Estrogen Receptor-Positive/HER2-Negative Metastatic Breast Cancer Background: Why Conduct This Study? In recent years, cancer immunotherapies have achieved transformative success, with notable efficacy in “hot tumors,” such as triple-negative breast cancer (TNBC), which hav...

High Cellular Plasticity State of Medulloblastoma: Local Recurrence and Distant Dissemination

Medicine, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
medulloblastoma   cellular plasticity   recurrence   dissemination   PTPRZ1   tumor subpopulations   therapeutic target  

High Cellular Plasticity State of Pediatric Medulloblastoma: A Comprehensive Analysis of Local Recurrence and Distant Dissemination Research Background Medulloblastoma (MB) is a highly heterogeneous pediatric intracranial malignancy. While current treatments (surgery, radiotherapy, and chemotherapy) improve survival rates after initial treatment, r...

Endocrine-targeting therapies shift the breast microbiome to reduce estrogen receptor-positive breast cancer risk

Medicine, Endocrinology, Oncology, Life Sciences, Cell Biology, Biochemistry, Microbiology,
breast microbiome   endocrine-targeting therapies   breast cancer risk   probiotics   tissue metabolism   tumorigenesis   estrogen receptor  

Exploring the Impact of Endocrine-Targeting Therapies on Breast Microbiota and Their Potential in Breast Cancer Prevention and Treatment Breast cancer is one of the most commonly diagnosed types of cancer in women. Despite significant advancements in diagnosis and treatment, the mortality rate remains high, with over 40,000 deaths annually in the U...