The Maternal X Chromosome Affects Cognition and Brain Ageing in Female Mice

Medicine, Neurology, Life Sciences, Cell Biology, Genetics,
maternal X chromosome   cognitive function   brain ageing   female mice   genomic imprinting   hippocampus   CRISPR  

The Impact of the Maternal X Chromosome on Cognition and Brain Aging in Female Mice Background Introduction In mammals, female cells possess two X chromosomes, one from the mother (maternal X chromosome, Xm) and one from the father (paternal X chromosome, Xp). During embryonic development, one of the X chromosomes is randomly inactivated, a process...

Immune Evasion Through Mitochondrial Transfer in the Tumour Microenvironment

Medicine, Oncology, Life Sciences, Cell Biology, Immunology,
tumour microenvironment   mitochondrial transfer   immune evasion   mitochondrial DNA mutations   immune checkpoint inhibitors   melanoma   non-small-cell lung cancer  

Mitochondrial Transfer and Immune Evasion Mechanisms in the Tumor Microenvironment Academic Background Tumor cells evade immune system attacks, particularly by T cells, through various mechanisms in the Tumor Microenvironment (TME). Although Immune Checkpoint Inhibitors (ICIs) have achieved significant progress in the treatment of various cancers, ...

Precise Modelling of Mitochondrial Diseases Using Optimized Mitobes

Medicine, Life Sciences, Cell Biology, Biochemistry, Genetics,
mitochondrial diseases   gene editing   Mitobes   mouse models   off-target effects   phenotypic evaluation   genetic mutations  

Precise Modeling of Mitochondrial Diseases: Research Based on Optimized Mitobes Academic Background Mitochondrial diseases are a group of genetic disorders caused by mutations in mitochondrial DNA (mtDNA), which affect cellular energy metabolism and lead to dysfunction in multiple organs. Mitochondrial DNA mutations can be homoplasmic (affecting al...

Multiscale Footprints Reveal the Organization of Cis-Regulatory Elements

Information Science, Artificial Intelligence, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
cis-regulatory elements   chromatin accessibility   transcription factors   deep learning   single-cell sequencing   genomics   cell differentiation  

Multiscale Footprints Reveal the Role of Cis-Regulatory Elements in Cell Differentiation and Aging Background Introduction The regulation of gene expression is a key mechanism in cell fate determination and disease development, and cis-regulatory elements (CREs) play a crucial role in this process. CREs dynamically regulate gene expression by bindi...

Rapid and Scalable Personalized ASO Screening in Patient-Derived Organoids

Medicine, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
personalized therapeutics   antisense oligonucleotides   rare diseases   organoid models   gene therapy   Duchenne muscular dystrophy   stem cells  

Establishment of a Personalized Antisense Oligonucleotide (ASO) Screening Platform Based on Patient-Derived Organoids Academic Background In recent years, with the rapid development of genome sequencing technologies, an increasing number of rare genetic diseases have been found to be associated with specific gene mutations. Antisense oligonucleotid...

Predicting Outcomes in Esophageal Squamous Cell Carcinoma Using scRNA-seq and Bulk RNA-seq: A Model Development and Validation Study

Medicine, Oncology, Life Sciences, Cell Biology, Immunology,
Esophageal squamous cell carcinoma   Glucose metabolism   Immune infiltration   Prognosis   Single-cell RNA sequencing   Bulk RNA sequencing   Bioinformatics  

Prognostic Prediction Model for Esophageal Squamous Cell Carcinoma Based on Single-Cell RNA Sequencing and Bulk RNA Sequencing Research Background Esophageal Squamous Cell Carcinoma (ESCC) is one of the most common malignant tumors globally, particularly prevalent in East Asia. Despite existing treatment methods such as surgery, endoscopic resectio...