Comparative Molecular Taxonomics of Neurons in the Cingulate Cortex of Rhesus Monkey and Mouse via Single-Nucleus RNA Sequencing

Life Sciences, Cell Biology, Biophysics,
Rhesus Monkey   Mouse   Single-Nucleus RNA Sequencing   Neurons   Molecular Taxonomy   Cingulate Cortex  

Comparative Study of Molecular Taxonomy in Cortical Regions of Primates and Rodents The brain structure is complex, showing high complexity in both molecular and cellular composition. Current research on brain molecular taxonomy is mainly based on rodents. However, although primates and rodents have common ancestors, they diverged through different...

High Magnesium Promotes the Recovery of Binocular Vision from Amblyopia via TRPM7

Medicine, Neurology, Ophthalmology, Life Sciences, Cell Biology, Biochemistry, Biophysics,
Amblyopia   Magnesium   TRPM7   Binocular Vision   Neural Plasticity   Visual Cortex   Molecular Mechanism  

Mechanism Study of High Magnesium Promoting Binocular Vision Recovery in Amblyopia Patients: The Role of TRPM7 Abnormal visual experiences during critical periods of brain development can lead to visual function deficits, such as amblyopia. Current research suggests that high magnesium (Mg^2+) supplementation can restore synaptic plasticity in the ...

Microglial EPOR Contribute to Sevoflurane-Induced Developmental Fine Motor Deficits Through Synaptic Pruning in Mice

Medicine, Anesthesiology, Neurology, Life Sciences, Cell Biology, Biochemistry,
Erythropoietin   Microglia   Synaptic pruning   Sevoflurane   Fine motor deficits  

Contemporary Anesthesia Safety Research: New Pathological Mechanism of Fine Motor Deficits in Mice With the advancement of modern anesthesia techniques, millions of lives rely on successful surgeries each year. However, various clinical studies, including those by the Mayo Anesthesia Safety in Kids (MASK) group, suggest that children who undergo mu...

Fluoxetine Rescues Excessive Myelin Formation and Psychological Behaviors in a Murine PTSD Model

Medicine, Basic Medical Sciences, Psychiatry, Neurology, Life Sciences, Cell Biology,
PTSD   myelination   oligodendroglial differentiation   fluoxetine   Wnt signaling  

Fluoxetine Rescues Excessive Myelin Formation and Psychological Behaviors in a Murine PTSD Model Background Post-traumatic stress disorder (PTSD) is a complex mental disorder characterized by spontaneous intrusions of traumatic memories, avoidance of trauma-related stimuli, negative emotions and cognitions, and hyperarousal. Although existing first...

Serum LDL Promotes Microglial Activation and Exacerbates Demyelinating Injury in Neuromyelitis Optica Spectrum Disorder

Medicine, Infectious Diseases, Rheumatology and Immunology, Neurology, Life Sciences, Cell Biology,
Neuromyelitis Optica Spectrum Disorder   Low-Density Lipoprotein   Microglia   Blood-Brain Barrier   Lipid Metabolism   Glycolysis   Demyelinating Injury  

Study on Serum LDL Promoting Microglial Activation and Exacerbating Demyelination in Neuromyelitis Optica Spectrum Disorder Neuromyelitis Optica Spectrum Disorder (NMOSD) is an autoimmune inflammatory demyelinating disease of the central nervous system (CNS), often accompanied by disruption of the blood-brain barrier (BBB). Dysfunction of lipid met...

Nucleus Accumbens Corticotropin-Releasing Hormone Neurons Projecting to the Bed Nucleus of the Stria Terminalis Promote Wakefulness and Positive Affective State

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry,
corticotropin-releasing hormone   wakefulness   anxiolysis   nucleus accumbens   bed nucleus of the stria terminalis  

Nucleus Accumbens Corticotropin-Releasing Hormone Neurons Project to Bed Nucleus of the Stria Terminalis to Regulate Wakefulness and Positive Emotional States Background The nucleus accumbens (NAc) plays a crucial role in regulating motivation, reward, and many behaviors that depend on high levels of arousal. However, research on the neural mechani...