Inhibition of YIPF2 Improves the Vulnerability of Oligodendrocytes to Human Islet Amyloid Polypeptide

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry,
diabetic encephalopathy   human islet amyloid polypeptide   oligodendrocytes   yeast Rab GTPase-interacting protein 2   monocarboxylate transporters   CD147  

Study on YIPF2 Inhibitors Improving Oligodendrocyte Susceptibility to Human Islet Amyloid Polypeptide With the dramatic increase in global diabetes prevalence, the harm of diabetes complications is becoming increasingly prominent. Among them, Diabetic Encephalopathy (DE), as the most common complication in type 2 diabetes, severely affects patients...

Transcutaneous Auricular Vagus Nerve Stimulation Ameliorates Preeclampsia-Induced Apoptosis of Placental Trophoblastic Cells via Inhibiting the Mitochondrial Unfolded Protein Response

Medicine, Obstetrics and Gynecology, Neurology, Life Sciences, Cell Biology, Biochemistry,
preeclampsia   transcutaneous auricular vagus nerve stimulation   acetylcholine   reactive oxygen species   mitochondrial unfolded protein response   placental trophoblastic cells  

Transcutaneous Auricular Vagus Nerve Stimulation Alleviates Preeclampsia-Induced Placental Trophoblast Apoptosis by Inhibiting Mitochondrial Unfolded Protein Response Research Background Preeclampsia is a severe obstetric complication affecting 2%-8% of pregnancies worldwide. This disease not only impacts the health of pregnant women but also serio...

Triggering Receptor Expressed on Myeloid Cells 2 Alleviated Sevoflurane-Induced Developmental Neurotoxicity via Microglial Pruning of Dendritic Spines in the CA1 Region of the Hippocampus

Medicine, Pediatrics, Anesthesiology, Neurology, Life Sciences, Cell Biology, Immunology,
CA1 neurons   dendritic spines   developmental neurotoxicity   microglia   sevoflurane   TREM2  

TREM2 Expression on Mouse Astrocytes Prevents Sevoflurane-Induced Developmental Neurotoxicity Through Microglial Pruning of Dendritic Spines in Hippocampal CA1 Region Research Background and Significance Sevoflurane is one of the most widely used anesthetics in pediatric anesthesia. Early multiple exposures to sevoflurane can lead to developmental ...

Amorfrutin B Compromises Hypoxia/Ischemia-Induced Activation of Human Microglia in a PPARγ-Dependent Manner: Effects on Inflammation, Proliferation Potential, and Mitochondrial Status

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
microglia   inflammation   selective PPARγ modulator   perinatal asphyxia   stroke  

Research on the Effects of Amorfrutin B on Human Microglia under Hypoxia/Ischemia Conditions: Anti-inflammatory Action, Proliferation Potential, and Mitochondrial State Based on the PPARγ Pathway Research Background Hypoxia/ischemia is a major cause of brain injury in both neonatal and adult populations. Perinatal asphyxia and ischemic stroke are l...

β-hydroxybutyrate improves the redox status, cytokine production, and phagocytic potency of glucose-deprived HMC3 human microglia-like cells

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
β-hydroxybutyrate   HMC3   cytokines   glucose deprivation   human microglia   phagocytosis  

Research Report: β-Hydroxybutyrate Improves Redox State, Cytokine Secretion, and Phagocytic Ability of Glucose-Deprived HMC3 Human Microglia Introduction Microglia are resident neuroimmune cells in the brain, accounting for 5-12% of total neuroglial cells, with strong migration, proliferation, and phagocytic abilities. For example, microglia mainta...

Epigallocatechin-3-Gallate Inhibits LPS/AβO-Induced Neuroinflammation in BV2 Cells Through Regulating the ROS/Txnip/NLRP3 Pathway

Medicine, Basic Medical Sciences, Neurology, Pharmacy, Life Sciences, Cell Biology, Biochemistry,
Alzheimer's Disease   Amyloid β   Epigallocatechin-3-Gallate   NLRP3 Inflammasome   Txnip  

Epigallocatechin-3-Gallate (EGCG) Inhibits Neuroinflammation in BV2 Cells by Regulating the ROS/TXNIP/NLRP3 Pathway Research Background Alzheimer’s Disease (AD) is a degenerative brain disorder primarily affecting the elderly, characterized by persistent cognitive dysfunction and behavioral impairment. The neuropathological changes in AD include β-...