BAG6 restricts pancreatic cancer progression by suppressing the release of IL33-presenting extracellular vesicles and the activation of mast cells

Medicine, Rheumatology and Immunology, Basic Medical Sciences, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
pancreatic cancer   extracellular vesicles   BAG6   mast cells   tumor microenvironment  

Research Report on the Mechanism of BAG6 Restricting Pancreatic Cancer Progression Research Background Pancreatic Ductal Adenocarcinoma (PDAC) has an extremely poor prognosis, with a median survival of only 6 months, urgently requiring new treatment methods. In recent years, studies have found that extracellular vesicles (EVs) released by tumor cel...

Targeting the Intestinal Circadian Clock by Meal Timing Ameliorates Gastrointestinal Inflammation

Medicine, Rheumatology and Immunology, Gastroenterology, Life Sciences, Cell Biology, Immunology, Microbiology,
intestinal circadian clock   gastrointestinal inflammation   IBD   restricted feeding   microbiota  

Research on Alleviating Gastrointestinal Inflammation by Adjusting Intestinal Circadian Rhythm through Feeding Time Background Information Impaired expression of intestinal circadian rhythm genes has been observed in biopsies from patients with inflammatory bowel disease (IBD). Disruption of circadian rhythms, such as that occurring in shift worker...

Exportin 1 governs the immunosuppressive functions of myeloid-derived suppressor cells in tumors through Erk1/2 nuclear export

Medicine, Rheumatology and Immunology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
tumor   myeloid-derived suppressor cells   Exportin 1   MAPK pathway   anti-tumor immunity  

Paper Report Research Background Myeloid-Derived Suppressor Cells (MDSCs) are a major driving force in tumor immune suppression. Understanding their mechanisms can provide new therapeutic targets to improve anti-tumor immunity, as the development and immunosuppressive function of these cells directly affect anti-tumor immune responses. In preclinic...

Depleting Profibrotic Macrophages Using Bioactivated In Vivo Assembly Peptides Ameliorates Kidney Fibrosis

Medicine, Rheumatology and Immunology, Basic Medical Sciences, Nephrology, Life Sciences, Cell Biology, Biochemistry, Immunology,
renal fibrosis   immune microenvironment   profibrotic macrophage   bioactivated in vivo assembly   cell death  

Preface Chronic Kidney Disease (CKD) is a condition characterized by long-term damage to kidney structure, leading to gradual loss of kidney function. Currently, about 10% of adults worldwide are affected by CKD, causing approximately 1.2 million deaths annually. Renal fibrosis is one of the pathological manifestations of CKD, characterized by the ...

Mechanistic Study on SENP6 Regulation of IFN-I Signaling Pathway and Antiviral Activity

Medicine, Infectious Diseases, Rheumatology and Immunology, Life Sciences, Cell Biology, Biochemistry, Immunology,
SENP6   Sumoylation   USP8   IFNAR2   Antiviral Activity  

Academic Background and Research Question In antiviral efficacy research, type I interferon (IFN-I) has been widely used clinically due to its broad-spectrum antiviral properties. However, the specific signaling mechanism and regulatory modes of IFN-I remain complex and not fully elucidated. In light of this, experts have begun to pay attention to ...

Chaperone- and PTM-mediated Activation of IRF1 Tames Radiation-induced Cell Death and the Inflammatory Response

Medicine, Rheumatology and Immunology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Interferon Regulatory Factor 1   Ionizing Radiation   Nuclear Translocation   Posttranslational Modification   Transcription Regulation  

Study on IRF1 Transcriptional Activation Regulation of Radiation-Induced Cell Death and Inflammatory Response under Mutagenic Stress Background Recent multi-omics studies have revealed the key role of structural cells in immune regulation, but the mechanism remains unclear. Based on this, this study mainly explores how the transcriptional activatio...