Brain-Derived Exosomal circRNAs in Plasma Serve as Diagnostic Biomarkers for Acute Ischemic Stroke

Medicine, Emergency Medicine, Medical Laboratory Science, Neurology, Life Sciences, Cell Biology, Immunology,
acute ischemic stroke   plasma   brain-derived exosomes   circRNA   biomarker  

Brain-Derived Exosomal Circular RNAs in Plasma as Diagnostic Biomarkers for Acute Ischemic Stroke Acute ischemic stroke (AIS), commonly known as stroke, is a serious condition characterized by interrupted blood flow to the brain, resulting in tissue damage and neurological deficits. Early diagnosis is crucial for effective intervention and manageme...

JAK1/2 Regulates Synergy Between Interferon Gamma and Lipopolysaccharides in Microglia

Medicine, Rheumatology and Immunology, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
microglia   LPS   interferons   JAK-STAT  

JAK1/2 Regulates the Synergistic Effect Between Interferon γ and Lipopolysaccharide in Microglia A research paper titled “JAK1/2 Regulates the Synergistic Effect Between Interferon γ and Lipopolysaccharide in Microglia” was published in the Journal of Neuroimmune Pharmacology in 2024. This article was completed by scholars Alexander P. Young and Ei...

β-sitosterol alleviates neuropathic pain by affecting microglia polarization through inhibiting tlr4/nf-κb signaling pathway

Medicine, Neurology, Pharmacy, Life Sciences, Cell Biology, Biochemistry, Immunology,
β-sitosterol   tlr4   nf-κb   gmi-r1   inflammation   sciatica  

β-Sitosterol Alleviates Neuropathic Pain by Inhibiting the TLR4/NF-κB Signaling Pathway Background Neuropathic pain is a common and difficult-to-treat chronic pain condition in clinical practice, with complex and not fully understood etiology. Research has shown that neuroinflammation is one of the main causes of chronic neuropathic pain. Microglia...

Alleviating CB2-dependent ER stress and mitochondrial dysfunction improves chronic cerebral hypoperfusion-induced cognitive impairment

Medicine, Geriatrics, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
chronic cerebral hypoperfusion   cognitive impairment   endoplasmic reticulum stress   endocannabinoid system   fatty acid amide hydrolase   mitochondria  

Research Overview and Background With the acceleration of global aging, the incidence of ischemic cerebrovascular diseases is also rising significantly. Elderly people over 65 are particularly susceptible to cognitive decline caused by cerebral ischemia, making Chronic Cerebral Hypoperfusion (CCH) a major cause of cognitive impairment and Vascular ...

GPR34 Senses Demyelination to Promote Neuroinflammation and Pathologies

Medicine, Rheumatology and Immunology, Neurology, Life Sciences, Cell Biology, Immunology, Biophysics,
neuroinflammation   GPCRs   microglia   myelin debris   immune response   demyelination-associated diseases  

Background Introduction Sterile neuroinflammation is an important factor driving various neurological diseases. Myelin debris, released during the demyelination process in various neurological diseases (such as stroke, spinal cord injury (SCI), multiple sclerosis (MS), traumatic brain injury (TBI), and neurodegenerative diseases), can act as an inf...

BAG6 restricts pancreatic cancer progression by suppressing the release of IL33-presenting extracellular vesicles and the activation of mast cells

Medicine, Rheumatology and Immunology, Basic Medical Sciences, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
pancreatic cancer   extracellular vesicles   BAG6   mast cells   tumor microenvironment  

Research Report on the Mechanism of BAG6 Restricting Pancreatic Cancer Progression Research Background Pancreatic Ductal Adenocarcinoma (PDAC) has an extremely poor prognosis, with a median survival of only 6 months, urgently requiring new treatment methods. In recent years, studies have found that extracellular vesicles (EVs) released by tumor cel...