Academic Background G protein-coupled receptors (GPCRs) are the most abundant family of cell surface receptors in the human body and are also the most common targets of FDA-approved drugs. GPCRs play a crucial role in the treatment of various diseases, including pain, diabetes, cardiovascular diseases, and cancer. However, drug development targetin...
Academic Background Cancer immunotherapy has become a hot topic in cancer research in recent years, with its core goal being to activate the patient’s own immune system to recognize and eliminate cancer cells. However, cancer cells evade immune system attacks through various mechanisms, one of which is the expression of the “don’t eat me” signal mo...
Academic Background The completion of the Human Genome Project has greatly advanced our understanding of complex biological processes at the genome-wide level. However, only about 1% of the genome encodes proteins, with the majority consisting of non-coding regions that produce abundant non-coding RNAs (ncRNAs), such as long non-coding RNAs (lncRNA...
Breast cancer is one of the most common malignant tumors among women worldwide, with a complex pathogenesis involving multiple gene mutations and signaling pathway abnormalities. Homologous Recombination Deficiency (HRD) is a significant molecular characteristic in breast cancer, closely related to patients’ sensitivity to PARP inhibitor (PARPi) th...
In recent years, the significant role of the human gut microbiota (HGM) in the metabolism of drugs and nutrients has gradually been recognized. The gut microbiota not only affects the bioavailability of orally administered drugs but also participates in the biotransformation of drugs and bioactive molecules through its metabolic enzymes, thereby in...
In recent years, the role of gut microbiota in health and disease has garnered widespread attention. Research indicates that the diversity and composition of gut microbiota are closely related to the development and progression of cardiovascular disease (CVD). CVD is one of the leading causes of death globally, and inflammation plays a significant ...