SP-DTI: Subpocket-Informed Transformer for Drug–Target Interaction Prediction

Chemistry, Medicinal Chemistry, Information Science, Computer Science, Artificial Intelligence, Life Sciences, Biochemistry, Bioengineering,
Drug-Target Interaction   Deep Learning   Subpocket Analysis   Transformer Model   Drug Discovery  

Academic Background Drug-Target Interaction (DTI) prediction is a critical step in drug discovery, significantly reducing the cost and time of experimental screening. However, despite the advancements in deep learning that have improved the accuracy of DTI prediction, existing methods still face two major challenges: lack of generalizability and ne...

Glutamate Dehydrogenase 1-Catalytic Glutaminolysis Feedback Activates EGFR/PI3K/AKT Pathway and Reprograms Glioblastoma Metabolism

Medicine, Neurology, Oncology, Life Sciences, Biochemistry,
glutaminolysis   EGFR/PI3K/AKT pathway   glioblastoma   metabolic reprogramming   glutamate dehydrogenase 1  

Academic Background Glioblastoma (GBM) is one of the most aggressive and heterogeneous central nervous system tumors, with an extremely poor prognosis. Despite the emergence of novel therapies such as anti-angiogenic treatments and immunotherapy in recent years, the survival period of GBM patients remains very limited. GBM cells exhibit unique meta...

Inhibiting Cell Inspection Points Intervention via Injectable Short Fibers for Reversing Neural Cell Senescence

Medicine, Neurology, Neurosurgery, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
neural cell senescence   inspection point   short fibers   spinal cord   genome homeostasis  

Background Introduction Spinal Cord Injury (SCI) is a significant challenge in the medical field, particularly in terms of neural function recovery. Research indicates that neurons play a crucial role in spinal cord regeneration, but in complex pathological environments, neurons are influenced by various factors, leading to rapid senescence. Senesc...

A Time-Scheduled Oxygen Modulation System Facilitates Bone Regeneration by Powering Periosteal Stem Cells

Medicine, Orthopedics, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
bone regeneration   periosteal stem cells   remote control   oxygen delivery   rapid neovascularization  

Academic Background During tissue repair, chronic hypoxia negatively impacts the functionality of stem cells. Periosteal Stem Cells (PSCs), as the primary contributors to bone repair, exhibit unclear behavior under hypoxic conditions. While hypoxia may be beneficial for certain stem cells in the early stages of tissue repair, prolonged hypoxia can ...

High-Efficiency Base Editing in the Retina of Primates and Human Tissues

Medicine, Ophthalmology, Life Sciences, Biochemistry, Bioengineering, Genetics,
base editing   retina   gene therapy   primates   Stargardt disease  

High-precision Base Editing Technology in Primates and Human Retina Research Background Stargardt disease is a currently untreatable, inherited neurodegenerative disease that leads to macular degeneration and blindness due to loss-of-function mutations in the ABCA4 gene. The protein encoded by the ABCA4 gene is a membrane lipid flippase localized i...

Role of Major Cardiovascular Surgery-Induced Metabolic Reprogramming in Acute Kidney Injury in Critical Care

Medicine, Nephrology, Cardiovascular System, Life Sciences, Biochemistry,
major cardiovascular surgery   metabolism   metabolomics   amino acid   TCA cycle   citric acid   acylcarnitines   acute kidney injury  

The Role of Major Cardiovascular Surgery-Induced Metabolic Reprogramming in Acute Kidney Injury: A Metabolomics Study Academic Background Cardiovascular diseases are the leading cause of death worldwide, accounting for over 17.9 million deaths annually, which is 32% of all deaths. As the disease burden increases, about one-third of patients may req...