The Effects of Fermented Vegetables on the Gut Microbiota for Prevention of Cardiovascular Disease

Medicine, Gastroenterology, Cardiovascular System, Life Sciences, Biochemistry, Microbiology,
gut microbiota   cardiovascular disease   fermented vegetables   inflammation   C-reactive protein  

In recent years, the role of gut microbiota in health and disease has garnered widespread attention. Research indicates that the diversity and composition of gut microbiota are closely related to the development and progression of cardiovascular disease (CVD). CVD is one of the leading causes of death globally, and inflammation plays a significant ...

Seeding and Feeding Milestones: The Role of Human Milk Microbes and Oligosaccharides in the Temporal Development of Infant Gut Microbiota

Medicine, Pediatrics, Life Sciences, Biochemistry, Microbiology,
breast milk   oligosaccharides   gut microbiota   infant   microbes  

The Key Role of Human Milk Microbes and Oligosaccharides in Infant Gut Microbiota Development Academic Background The development of infant gut microbiota is crucial in early life, and breastfeeding is one of the key drivers of this process. Human milk not only provides essential nutrients for infants but also contains a rich array of microbes and ...

Pro-inflammatory and Hyperinsulinaemic Dietary Patterns are Associated with Specific Gut Microbiome Profiles: A TwinsUK Cohort Study

Medicine, Endocrinology, Gastroenterology, Life Sciences, Biochemistry, Microbiology,
pro-inflammatory diet   hyperinsulinaemic diet   gut microbiome   insulin resistance   chronic inflammation  

In recent years, the role of the gut microbiome in human health and disease has garnered significant attention. Research indicates that gut microbial dysbiosis is closely associated with various chronic diseases, such as obesity, inflammatory bowel disease, cancer, and neurodegenerative disorders. Diet, as a critical factor influencing the gut micr...

RNA Binding Protein with Multiple Splicing (RBPMS) Promotes Contractile Phenotype Splicing in Human Embryonic Stem Cell-Derived Vascular Smooth Muscle Cells

Medicine, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry,
RNA binding protein   vascular smooth muscle cells   splicing   embryonic stem cells   contractile phenotype  

The Critical Role of RNA-Binding Protein RBPMS in Vascular Smooth Muscle Cells Academic Background Vascular Smooth Muscle Cells (VSMCs) are the primary structural components of large arteries. In healthy blood vessels, VSMCs exhibit a mature contractile phenotype, responsible for regulating vascular tone and blood flow. However, VSMCs possess pheno...

DeepES: Deep Learning-Based Enzyme Screening for Identifying Orphan Enzyme Genes

Information Science, Computer Science, Artificial Intelligence, Life Sciences, Biochemistry, Bioengineering,
deep learning   enzyme screening   orphan enzymes   biosynthetic gene clusters   human gut microbiota  

Academic Background With the rapid advancement of sequencing technology, scientists have been able to obtain a vast amount of protein sequence data, including many enzyme sequences. However, despite the establishment of large enzyme databases such as the Kyoto Encyclopedia of Genes and Genomes (KEGG) and BRENDA, sequence information for many enzyme...

FlowPacker: Protein Side-Chain Packing with Torsional Flow Matching

Information Science, Computer Science, Artificial Intelligence, Life Sciences, Biochemistry, Bioengineering,
protein side-chain packing   torsional flow matching   equivariant graph attention networks   protein structure prediction   artificial intelligence  

The three-dimensional structure of a protein is determined by its amino acid sequence, and the function of the protein is highly dependent on its three-dimensional structure. The side-chain conformations of proteins play a crucial role in protein folding, protein-protein interactions, and de novo protein design. Accurate prediction of protein side-...