MassiveFold: Unveiling AlphaFold’s Hidden Potential with Optimized and Parallelized Massive Sampling

Information Science, Computer Science, Artificial Intelligence, Life Sciences, Biochemistry, Biophysics,
AlphaFold   protein structures   massive sampling   GPU optimization   parallelization   antibody-antigen   protein assemblies  

Interpretation of “MassiveFold: Unveiling AlphaFold’s Hidden Potential with Optimized and Parallelized Massive Sampling” Background and Research Questions Protein structure prediction is a crucial area in life sciences, vital for understanding fundamental mechanisms in molecular biology. Recently, DeepMind’s AlphaFold achieved revolutionary progres...

The Relationship Between Cancer Risk and Epigenetic Age Acceleration After Stroke

Medicine, Environmental and Public Health, Basic Medical Sciences, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
stroke   cancer risk   epigenetic clock   DNA methylation   biological age acceleration  

Study on the Association Between Long-Term Cancer Risk and Epigenetic Age in Stroke Survivors Background and Significance Cancer and stroke are leading global causes of morbidity and mortality, with their association being increasingly recognized. Statistics show that about 6% of cancer patients experience a stroke during their lifetime, while stro...

Integration of Multi-Omics Data Reveals the Role of Efferocytosis in Lung Adenocarcinoma Prognosis and Immunotherapy

Medicine, Basic Medical Sciences, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
lung adenocarcinoma   efferocytosis   single-cell RNA-seq   prognosis   immunotherapy   precision medicine   deep learning  

Research Report on Efferocytosis Features and Their Prognostic and Immunotherapy Associations in Lung Adenocarcinoma Background and Research Motivation Lung cancer is a leading cause of cancer-related mortality worldwide, with lung adenocarcinoma (LUAD) being the most common histological subtype. Due to the insidious nature of the disease and lack ...

Tumor Analysis of BRCA Carriers Reveals Genomic Similarities Despite Temporal Separation

Medicine, Basic Medical Sciences, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
BRCA   breast cancer   genomic profile   molecular analysis   early life events   genetic modifiers   preventive medicine  

Tumor Analysis of BRCA1/2 Carriers: Genomic Similarities Evident Across Different Time Points Breast cancer (BC) is the most common malignant tumor among women globally, with its pathogenesis predominantly sporadic, while familial hereditary cases account for only 5% to 10%. Among various pathogenic molecules, mutations in the BRCA1/2 genes (Pathog...

The Role of Radioresistant-Related Telomere Genes in the Prognosis and Immune Infiltration of Lung Adenocarcinoma

Medicine, Respiratory System, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
lung adenocarcinoma   radiotherapy   telomere genes   immune infiltration   prognostic model  

The Impact of Radioresistant-Related Telomere Genes on Prognosis and Immune Infiltration in Lung Adenocarcinoma Lung adenocarcinoma (LUAD), a common subtype of non-small cell lung cancer (NSCLC), has a high incidence and mortality rate. Despite significant progress in early detection and treatment, the overall survival (OS) rate of LUAD patients re...

Assessing Sustained B-Cell Depletion and Disease Activity in a French Multiple Sclerosis Cohort Treated by Long-Term IV Anti-CD20 Antibody Therapy

Medicine, Infectious Diseases, Neurology, Medical Imaging, Life Sciences, Biochemistry, Immunology,
multiple sclerosis   anti-CD20   B-cell depletion   disease activity   long-term therapy   adverse events   immunotherapy  

Long-term Intravenous Anti-CD20 Antibody Therapy Assessment in a French Multiple Sclerosis Cohort Background and Research Motivation Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease affecting the central nervous system, leading to varying degrees of physical and cognitive impairment. Recent Phase II and III clinical trials of...