Structural Basis of Antagonist Selectivity in Endothelin Receptors

Chemistry, Medicinal Chemistry, Medicine, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Immunology,
antagonist   endothelin receptors   structural biology   drug design   vascular homeostasis  

Deciphering Antagonist Selectivity of Endothelin Receptors: Insights from Cryo-EM-Based Structural Studies Academic Background Endothelin (ET) is a potent vasoconstrictor peptide that plays a significant role in regulating cardiovascular functions. The endothelin family includes ET-1, ET-2, and ET-3, which regulate vascular tone and cardiovascular ...

A Conditional Protein Diffusion Model Generates Artificial Programmable Endonuclease Sequences with Enhanced Activity

A Conditional Protein Diffusion Model Generates Artificial Programmable Endonuclease Sequences with Enhanced Activity

Information Science, Computer Science, Artificial Intelligence, Life Sciences, Biochemistry, Bioengineering, Genetics, Biophysics,
protein design   deep learning   artificial endonucleases   conditional diffusion model   enhanced activity  

Deep Learning-Driven Protein Design: Generating Functional Protein Sequences Using Conditional Diffusion Models Proteins are at the core of life sciences research and applications, offering countless possibilities due to their diversity and functional complexity. With advancements in deep learning technologies, protein design has reached a new pinn...

Targeting SNRNP200-Induced Splicing Dysregulation as an Immunotherapy Opportunity for Glycolytic Triple-Negative Breast Cancer

Medicine, Infectious Diseases, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
triple-negative breast cancer   SNRNP200   glycolysis   metabolic dysregulation   immunotherapy  

Targeting SNRNP200-Induced Splicing Dysregulation: A New Strategy for Immunotherapy in Glycolytic Triple-Negative Breast Cancer Background Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, characterized by extremely high recurrence and mortality rates. Despite significant recent advances in research on TNBC subty...

Complex Mosaicism and Aneuploid Cells in Human Embryo Development

Medicine, Obstetrics and Gynecology, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Genetics,
human embryo   mosaicism   aneuploidy   single-cell sequencing   embryo development  

Study of Complex Mosaicism in Human Embryos: Revealing Extensive Aneuploidy During Early Embryonic Development Background and Research Objectives Pre-implantation Genetic Testing for Aneuploidy (PGT-A) is a widely used technology in in vitro fertilization (IVF) aimed at screening out abnormal embryos to improve implantation and live birth rates. Ho...

Mechanisms of MED23 in Regulating Oligodendrocyte Differentiation and Myelination

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics, Microbiology,
MED23   oligodendrocytes   myelination   nervous system   transcription regulation  

Cross-Disciplinary Breakthrough: How Mediator Med23 Regulates Molecular Mechanisms of Neural Myelination Background and Research Objective Myelin is the multilayered membrane structure that wraps around axons in the central nervous system (CNS), and its integrity is crucial for neural signal conduction and overall nervous system function. When myel...

Deciphering the Topological Landscape of Glioma: A Framework Based on Network Theory

Medicine, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology, Genetics,
glioma   glioma stem cell   gene regulatory network   network dynamics   endogenous network theory   energy landscape  

Deciphering the Topological Landscape of Glioma: A Study Based on a Network Theory Framework Glioma stem cells (GSCs) are recognized as key factors in glioma recurrence and treatment resistance, making them an important focus for new therapeutic approaches. However, the limited understanding of the role of GSCs in the hierarchy of glioma has sparke...