Bacterial Toxins Induce Non-Canonical Migracytosis to Aggravate Acute Inflammation

Medicine, Infectious Diseases, Emergency Medicine, Life Sciences, Cell Biology, Biochemistry, Immunology, Microbiology,
bacterial toxins   migracytosis   acute inflammation   C. difficile   small GTPase  

Report on the Study of Bacterial Toxins Inducing Non-Canonical Migracytosis and Aggravating Acute Inflammation Background and Research Objectives In recent years, the discovery of migrasomes, a new type of membrane structure, has gained significant attention in the scientific community for its role in cell migration and various biological functions...

Stem Cell Transplantation Extends the Reproductive Lifespan of Naturally Aging Cynomolgus Monkeys

Medicine, Obstetrics and Gynecology, Geriatrics, Endocrinology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
stem cell transplantation   reproductive lifespan   ovarian aging   oxidative damage   cellular inflammation  

Stem Cell Transplantation Extends the Reproductive Lifespan of Naturally Aging Cynomolgus Monkeys Background of the Study The ovary is a crucial organ for female reproduction and health, responsible for producing oocytes and secreting sex hormones. As women age, ovarian reserves gradually decline, eventually leading to menopause, which brings about...

Selective Advantage of Mutant Stem Cells in Human Clonal Hematopoiesis Associated with Attenuated Response to Inflammation and Aging

Medicine, Hematology, Life Sciences, Biochemistry, Immunology, Genetics,
mutant stem cells   clonal hematopoiesis   inflammation   aging   selective advantage   DNMT3A mutation   TET2 mutation  

Selective Advantage of Clonal Hematopoietic Mutant Stem Cells in Aging and Inflammatory Responses Background and Research Motivation Clonal Hematopoiesis (CH) is an aging-related phenomenon in the hematopoietic system, where hematopoietic stem cells (HSCs) acquire specific somatic mutations and undergo expansion, causing a particular mutated cell l...

A Human Pluripotent Stem Cell-Based Somitogenesis Model Using Microfluidics

Life Sciences, Cell Biology, Biochemistry, Bioengineering, Biophysics,
human pluripotent stem cells   somitogenesis   microfluidics   biomechanics   morphogenesis  

Study of Somite Formation Model Based on Microfluidic System Background and Research Motivation The formation of somites plays a crucial role in vertebrate embryonic development, significantly influencing the layout and functionality of the embryonic musculoskeletal system. Somite formation involves the segmentation of bilateral presomitic mesoderm...

Increased Cholesterol Synthesis Drives Neurotoxicity in Patient Stem Cell-Derived Model of Multiple Sclerosis

Medicine, Neurology, Life Sciences, Biochemistry, Immunology,
cholesterol synthesis   multiple sclerosis   neurotoxicity   stem cells   inflammatory signaling   hypermetabolism   pharmacological treatment  

Lipid Metabolism Mechanisms in Neurodegenerative Diseases: A New Study on Multiple Sclerosis Multiple Sclerosis (MS) is a common inflammatory autoimmune demyelinating disease of the central nervous system (CNS). As the disease progresses, patients gradually experience neurological damage and disability. Although there have been advances in the trea...

A Distinct Metabolic and Epigenetic State Drives Trained Immunity in HSC-Derived Macrophages from Autoimmune Mice

Medicine, Rheumatology and Immunology, Hematology, Life Sciences, Cell Biology, Biochemistry, Immunology,
trained immunity   HSC   autoimmune   metabolic state   epigenetic  

Metabolic and Epigenetic States of HSC-Derived Macrophages in Autoimmune Diseases and Their Driving Mechanism of Trained Immunity Research Background In the context of autoimmune diseases (AD), studies have shown that prolonged activation of the immune system and inflammatory responses affect not only mature immune cells but also have profound effe...