Assessing Sustained B-Cell Depletion and Disease Activity in a French Multiple Sclerosis Cohort Treated by Long-Term IV Anti-CD20 Antibody Therapy

Medicine, Infectious Diseases, Neurology, Medical Imaging, Life Sciences, Biochemistry, Immunology,
multiple sclerosis   anti-CD20   B-cell depletion   disease activity   long-term therapy   adverse events   immunotherapy  

Long-term Intravenous Anti-CD20 Antibody Therapy Assessment in a French Multiple Sclerosis Cohort Background and Research Motivation Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease affecting the central nervous system, leading to varying degrees of physical and cognitive impairment. Recent Phase II and III clinical trials of...

Optimized Nutrition in Mitochondrial Disease Correlates to Improved Muscle Fatigue, Strength, and Quality of Life

Medicine, Basic Medical Sciences, Medical Laboratory Science, Neurology, Gastroenterology, Life Sciences, Biochemistry, Immunology,
mitochondrial disease   nutritional status   muscle fatigue   quality of life   macronutrients   inadequate calorie intake   nutritional intervention  

Optimized Nutritional Interventions Improve Muscle Fatigue, Strength, and Quality of Life in Patients with Primary Mitochondrial Disease Background Introduction Primary mitochondrial disease (PMD) encompasses a group of disorders caused by mutations in mitochondrial DNA or nuclear DNA, affecting systemic energy metabolism. The prevalence is approxi...

Neuroprotection with Glyceryl Trinitrate Post-Endovascular Therapy in Acute Ischemic Stroke: A Pilot Randomized Controlled Trial

Medicine, Infectious Diseases, Basic Medical Sciences, Emergency Medicine, Neurology, Cardiovascular System, Life Sciences, Biochemistry,
acute ischemic stroke   glyceryl trinitrate   endovascular therapy   neuroprotection   randomized controlled trial  

Overview of Nitroglycerin-Based Neuroprotection in Acute Ischemic Stroke: A Pilot Randomized Controlled Trial Review Background and Research Objectives Acute ischemic stroke (AIS) is one of the leading global causes of disability and death. Despite the significant improvement in vascular recanalization rates and patient outcomes achieved with moder...

Magnetic Resonance-Guided Focused Ultrasound Thalamotomy Rebalances Atypical Functional Hierarchy in Patients with Essential Tremor

Medicine, Basic Medical Sciences, Neurology, Neurosurgery, Medical Imaging, Life Sciences, Biochemistry, Immunology,
magnetic resonance-guided   focused ultrasound   thalamotomy   essential tremor   functional gradient   brain functional framework   neuropathophysiology  

Research Report: Reshaping Functional Hierarchies in Medication-Refractory Essential Tremor Through MRgFUS Therapy Essential tremor (ET), a prevalent movement disorder, is characterized by involuntary limb tremors, particularly noticeable during specific tasks. While traditional pharmacological treatments and deep brain stimulation (DBS) have shown...

Therapeutic Effects of Combination of Nebivolol and Donepezil: Targeting Multifactorial Mechanisms in ALS

Chemistry, Medicinal Chemistry, Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Amyotrophic Lateral Sclerosis   Neurodegeneration   Multifactorial Mechanisms   Drug Combination Therapy   Motor Neuron Protection  

Report on ALS Treatment Study: Exploring the Multifaceted Mechanisms of Nebivolol and Donepezil Background and Research Objectives Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease marked by progressive loss of motor neurons in the spinal cord and brain, leading to severe muscle atrophy, functional decline, and eventual death...

Persistent NRG1 Type III Overexpression in Spinal Motor Neurons Has No Therapeutic Effect on ALS-Related Pathology in SOD1 G93A Mice

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology, Microbiology,
ALS   motor neurons   NRG1   SOD1   neurodegenerative disease   therapy   gene therapy  

Background and Research Motivation Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease affecting upper and lower motor neurons, leading to progressive muscle paralysis and eventual death. Currently, no effective treatments can significantly delay or halt ALS progression. While various ALS mouse models (such as those carry...