A New Protein Regulating Mitochondrial Function for Maintaining Hematopoietic Stem Cell Viability: The Role of Nynrin

A New Protein Regulating Mitochondrial Function for Maintaining Hematopoietic Stem Cell Viability: The Role of Nynrin

Medicine, Hematology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Hematopoietic Stem Cells   Mitochondrial Function   Nynrin   Radiation Tolerance   Cell Cycle  

Nynrin Protects Hematopoietic Stem Cell Function by Inhibiting Mitochondrial Permeability Transition Pore Opening Background and Research Motivation Hematopoietic stem cells (HSCs) are core cells that maintain the function of the hematopoietic system, showing unique adaptability to stress environments such as radiation damage. However, while conven...

Analyzing Embryo Dormancy at Single-Cell Resolution Reveals Dynamic Transcriptional Responses and Activation of Integrin-YAP/TAZ Prosurvival Signaling

Life Sciences, Cell Biology, Biochemistry,
embryo dormancy   single-cell transcriptomics   integrin signaling   YAP/TAZ   developmental potential   mouse embryo   transcriptional dynamics  

Dynamic Transcriptional Response and Activation of Integrin-YAP/TAZ Survival Signaling Pathway Revealed by Single-Cell Resolution Analysis of Embryo Dormancy Introduction Embryo dormancy, or diapause, is a unique reproductive adaptation that allows some mammals to pause embryonic development without compromising their developmental potential. Diapa...

Disruption of TGF-β signaling pathway is required to mediate effective killing of hepatocellular carcinoma by human iPSC-derived NK cells

Medicine, Hepatobiliary System, Oncology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology, Genetics,
TGF-β   signaling pathway   NK cells   hepatocellular carcinoma   iPSC   anti-tumor   immunotherapy  

Background Introduction Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, with a five-year survival rate of less than 20%, and treatment options are extremely limited. Traditional targeted drug therapies, such as Sorafenib and other kinase inhibitors, have been used to treat HCC, but their efficacy is limited and diffi...

Network-Wide Risk Convergence in Gene Co-Expression Identifies Reproducible Genetic Hubs of Schizophrenia Risk

Medicine, Psychiatry, Life Sciences, Biochemistry, Genetics,
gene co-expression   schizophrenia   genetic risk   neurons   GWAS   genome-wide association  

The Genetic Network Aggregation Mechanism for Schizophrenia Risk — Latest Research Interpretation from the Journal “Neuron” In recent years, genetic research on schizophrenia (SCZ) has made significant progress, particularly driven by genome-wide association studies (GWAS), revealing a large number of genetic variants associated with the disease. H...

Failure in a Population: Tauopathy Disrupts Homeostatic Set-Points in Emergent Dynamics Despite Stability in the Constituent Neurons

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry,
Tauopathy   Homeostatic Regulation   Neuronal Dynamics   Neurodegenerative Disease   Network Dynamics  

Disturbance of Neuronal Homeostasis and Disruption of Neuronal Network Dynamics Caused by Tau Proteinopathy Background and Research Objectives Homeostatic mechanisms play a crucial role in maintaining the stability of brain functions. Under normal circumstances, neuronal activity set-points, such as firing rates, are dynamically adjusted through ho...

Integration and Competition Between Space and Time in the Hippocampus

Medicine, Neurology, Life Sciences, Biochemistry, Biophysics,
hippocampus   space   time   neurons   memory  

A Review on the Mechanisms of Spatial and Temporal Integration and Competition in the Hippocampus Research Background and Significance In the human and animal brain, space and time comprise the primary dimensions of episodic memory, playing a crucial role in encoding information such as event sequences, locations, and durations. It has long been fo...