Protein Lactylation and Metabolic Regulation of the Zoonotic Parasite Toxoplasma gondii

Medicine, Infectious Diseases, Life Sciences, Biochemistry, Microbiology,
Toxoplasma gondii   lactylation   protein post-translational modification   metabolism   Chip-seq  

A Study on Protein Lactylation and Metabolic Regulation Reveals New Areas of Toxoplasma gondii Biology Background: Toxoplasma gondii is a globally distributed protozoan parasite that infects over 30% of the world’s population. It causes toxoplasmosis, a widespread zoonotic disease. The parasite has a complex life cycle, including sexual and asexual...

Sequence-Based Functional Metagenomics Reveals Novel Natural Diversity of Cu Resistance Gene copa in Environmental Microbiomes

Chemistry, Environmental Chemistry, Life Sciences, Biochemistry, Bioengineering, Microbiology,
Functional Metagenomics   Natural Diversity   Cu Resistance   Evolutionary Trace Analysis   Copper Tolerance  

Sequence-based Functional Metagenomics Reveals New Natural Diversity of Functional COPA Genes in Environmental Microbiomes The natural diversity of functional genes/proteins in environmental microbiomes is an essential component of evolutionary and bioengineering research. To gain a deeper understanding of the diversity of the copper (Cu) resistanc...

Decoding Human Biology and Disease Using Single-Cell Omics Technologies

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
single-cell omics   computational method   cellular heterogeneity   disease   cancer research  

Decoding Human Biology and Disease with Single-Cell Omics Technologies Background Introduction Cells are the fundamental units of life. A single fertilized egg can develop into an entire complex human body, composed of approximately 37 trillion cells organized into various tissues, organs, and systems. Traditional cell classification methods primar...

Novel Time-Dependent Multi-Omics Integration in Sepsis-Associated Liver Dysfunction

Medicine, Infectious Diseases, Hepatobiliary System, Medical Laboratory Science, Life Sciences, Biochemistry, Genetics,
multi-omics   omics technology   sepsis-associated liver dysfunction   single omics   time-dependent integration  

Time-Dependent Multi-Omics Integration in Sepsis-Associated Liver Dysfunction Introduction Sepsis, especially severe cases, causes multiple organ dysfunction due to systemic infection, resulting in up to 5 million deaths globally each year. Traditionally, Sepsis-Associated Liver Dysfunction (SALD) was considered a condition accompanied by jaundice ...

Protein Structure Prediction: Challenges, Advances, and the Shift of Research Paradigms

Information Science, Computer Science, Artificial Intelligence, Life Sciences, Cell Biology, Biochemistry, Biophysics,
protein folding   protein structure prediction   deep learning   transformer   language model  

Protein Structure Prediction: Challenges, Progress, and Shifts in Research Paradigms Protein structure prediction is an important interdisciplinary research topic that has attracted researchers from various fields including biochemistry, medicine, physics, mathematics, and computer science. Researchers have adopted multiple research paradigms to so...

A Review of Molecular Mechanisms in Cell Fate Determination During Early Mammalian Development

Life Sciences, Cell Biology, Biochemistry, Genetics,
cell fate determination   cellular heterogeneity   cell polarity   single-cell omics   mammalian preimplantation embryo  

Omics Perspective on Cell Fate Determination Mechanisms Background Introduction During early mammalian embryo development, a totipotent zygote undergoes several cell divisions and two rounds of cell fate determination, ultimately forming a mature blastocyst. In this process, as the embryo compresses, the establishment of apicobasal cell polarity br...