Leptin Receptor Reactivation Restores Brain Function in Early-Life lepr-Deficient Mice

Medicine, Basic Medical Sciences, Endocrinology, Neurology, Neurosurgery, Life Sciences, Cell Biology, Biochemistry,
leptin   obesity   neurogenesis   memory impairment   brain atrophy  

Reactivation of Insulin Receptors Can Restore Brain Function in Early Lepr-Deficient Mice Background Obesity is a chronic disease caused by excessive fat accumulation, affecting both body and brain health. Deficiency of the insulin receptor (Leptin receptor, Lepr) is considered an important factor in the pathogenesis of obesity. Insulin plays a cru...

Transcriptome Dynamics and Cell Dialogs Between Oocytes and Granulosa Cells in Mouse Follicle Development

Medicine, Obstetrics and Gynecology, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
oocyte   granulosa cell   transcriptome   folliculogenesis   cell dialog  

Transcriptome Dynamics and Cell Dialogue Between Oocytes and Granulosa Cells During Mouse Follicle Development Overview Follicle development and maturation is a complex, multi-stage process. During this process, dynamic gene expression in oocytes and surrounding somatic cells, as well as the dialogue between them, play crucial roles. This study rev...

Proteomic Stratification of Prognosis and Treatment Options for Small Cell Lung Cancer

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
small cell lung cancer   proteomics   prognosis   chemotherapy response   immunotherapy  

Proteomic Subtyping of Small Cell Lung Cancer: Analysis of Prognosis and Treatment Strategies Research Background Small Cell Lung Cancer (SCLC) is a highly malignant and heterogeneous cancer characterized by rapid growth, early metastasis, and drug resistance, which limits treatment options and challenges prognostic prediction models. Current genom...

Benchmarking Algorithms for Gene Set Scoring of Single-Cell ATAC-Seq Data

Information Science, Computer Science, Artificial Intelligence, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
single-cell ATAC-Seq   gene set scoring   pathway analysis   single-cell RNA-Seq   benchmark  

Benchmarking Gene Set Scoring Tools for Single-Cell ATAC-seq Data Authors: Xi Wang, Qiwei Lian, Haoyu Dong, Shuo Xu, Yaru Su, Xiaohui Wu Affiliations: Pasteurien College (Soochow University Medical College), Department of Automation, Xiamen University, School of Mathematics and Computer Science, Fuzhou University Corresponding Author: xhwu@suda.edu...

Molecular Evolution of Protein Sequences and Codon Usage in Monkeypox Viruses

Medicine, Infectious Diseases, Life Sciences, Cell Biology, Biochemistry, Genetics, Microbiology,
mpox virus   positive selection   opg027   accelerated evolution   codon usage bias  

Molecular Evolution of Monkeypox Virus Protein Sequences and Codon Usage Research Background The 2022 Monkeypox virus (MPXV) outbreak has caused significant global public health concern. However, the evolutionary mechanisms of MPXV remain not fully understood. MPXV is a linear double-stranded DNA virus belonging to the family Poxviridae, subfamily ...

The Effect of Sodium Butyrate on Gene Expression and Protein Modification in Streptomyces

Life Sciences, Biochemistry, Genetics, Microbiology,
silent gene cluster   streptomyces   sodium butyrate   protein modification   acetylation  

Multi-omics Data Reveals the Impact of Sodium Butyrate on Gene Expression and Protein Modification in Streptomyces Academic Background Streptomyces has attracted widespread attention due to its rich gene clusters and potential for producing a large number of natural products. Histone deacetylase (HDAC) inhibitors play an important role in histone m...