MGA Deletion Leads to Richter’s Transformation by Modulating Mitochondrial OXPHOS

Medicine, Basic Medical Sciences, Hematology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
MGA   Richter's transformation   mitochondria   OXPHOS   CLL  

MGA Deletion Promotes Richter’s Transformation by Regulating Mitochondrial Oxidative Phosphorylation This article mainly focuses on the transformation of chronic lymphocytic leukemia (CLL) into aggressive lymphoma, known as Richter’s Transformation (RT), exploring the function and molecular mechanism of MGA (MAX Gene Associated). MGA is a functiona...

Super-relaxed Myosins Contribute to Respiratory Muscle Hibernation in Mechanically Ventilated Patients

Medicine, Respiratory System, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Biophysics,
super-relaxed myosins   mechanical ventilation   respiratory muscle hibernation   ICU   diaphragm weakness  

The Impact of Super-Relaxed Myosin on Diaphragm Dysfunction in Ventilated Patients Background Weak diaphragm contraction is a common problem in patients receiving mechanical ventilation in intensive care units (ICUs). This leads to difficulties in weaning patients off ventilators, increases mortality rates, and imposes a significant economic burden...

Piplartine Attenuates Aminoglycoside-Induced TRPV1 Activity and Protects from Hearing Loss in Mice

Chemistry, Medicinal Chemistry, Medicine, Neurology, Pharmacy, Life Sciences, Biochemistry,
hearing loss   aminoglycosides   TRPV1   mouse model   protective mechanism  

Piplartine Attenuates Aminoglycoside-Induced TRPV1 Activity and Protects from Hearing Loss in Mice Academic Background Hearing loss is a serious global health problem affecting over 400 million people worldwide, according to the World Health Organization. Aminoglycoside antibiotics, while widely used in medicine due to their broad-spectrum antibact...

In Vivo Bruton's Tyrosine Kinase Inhibition Attenuates Alcohol-Associated Liver Disease by Regulating CD84-Mediated Granulopoiesis

Medicine, Infectious Diseases, Hepatobiliary System, Gastroenterology, Hematology, Life Sciences, Biochemistry, Immunology,
Bruton's Tyrosine Kinase   Alcohol-Associated Liver Disease   Granulopoiesis   Neutrophils   Liver Damage   Therapeutic Target  

Research Background Severe alcoholic hepatitis (ALD) is a fatal form of alcohol-associated liver disease (AALD). The course of ALD is usually accompanied by neutrophil infiltration in the liver, which significantly affects the severity of the condition. However, the specific effects of alcohol on neutrophil function remain unclear. Based on this, i...

Engineered Exosomes with a Photoinducible Protein Delivery System Enable CRISPR-Cas–Based Epigenome Editing in Alzheimer’s Disease

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology,
engineered exosomes   photoinducible protein   Alzheimer’s disease   CRISPR-Cas   epigenome editing   delivery system   memory improvement  

CRISPR-Cas-Based Epigenome Editing in Alzheimer’s Disease: Engineered Exosomes with a Photoinducible Protein Delivery System Background Alzheimer’s Disease (AD) is a common neurodegenerative disorder characterized by progressive decline in cognitive function and memory, with currently limited treatment options. Genome editing technologies, such as ...

Leptin Receptor Reactivation Restores Brain Function in Early-Life lepr-Deficient Mice

Medicine, Basic Medical Sciences, Endocrinology, Neurology, Neurosurgery, Life Sciences, Cell Biology, Biochemistry,
leptin   obesity   neurogenesis   memory impairment   brain atrophy  

Reactivation of Insulin Receptors Can Restore Brain Function in Early Lepr-Deficient Mice Background Obesity is a chronic disease caused by excessive fat accumulation, affecting both body and brain health. Deficiency of the insulin receptor (Leptin receptor, Lepr) is considered an important factor in the pathogenesis of obesity. Insulin plays a cru...