The SIRT1-Rab7 Axis Regulates NLRP3 and STING Activation in Sepsis-Induced Acute Lung Injury via Terminal Endosome-Dependent Mitophagy Academic Background Acute lung injury (ALI) is one of the leading causes of death in septic patients, primarily due to the pro-inflammatory changes and permeability defects in endothelial cells (ECs). Mitochondrial ...
Microcirculatory Disorders of Cerebral Blood Flow and the Hypoxic-Ischemic Microenvironment Related to Brain Metastasis Development Background and Research Motivation Brain metastasis (BM) is an increasing challenge in oncology due to its severe impact on neurological function, limited treatment options, and resulting poor prognosis. BM develops th...
Manifestations of Genomic-Level Intratumoral Tumor Heterogeneity in Multi-Region Patient-Derived Xenograft Models of Non-Small Cell Lung Cancer Academic Background and Research Motivation Patient-Derived Xenograft (PDX) models are widely used in cancer research. PDX models are established by transplanting human tumors into immunodeficient mice. The...
Unsaturation of Fatty Acids Promotes Pore-Forming Activity of Bax and Bak in Apoptosis Background Apoptosis is the major form of programmed cell death, involved in fundamental biological processes such as embryonic development, tissue homeostasis, and immune system functions. Dysregulation of apoptosis can lead to neurodegenerative diseases and tum...
Acetate Reprograms Tumor Metabolism and Promotes Immune Evasion and PD-L1 Expression by Upregulating c-myc Introduction Reprogramming of tumor metabolism is of great significance in cancer research, and acetate plays a crucial role in this process. In tumor cells, acetate is an important precursor of acetyl-CoA, which is used for energy production,...
Oxygen is an essential substance for all metazoan organisms on Earth, influencing biological processes under various physiological and pathological conditions. Although systems that induce acute hypoxic responses, including the hypoxia-inducible factor (HIF) pathway, have been identified, their mechanisms of action under prolonged hypoxia remain in...