NCAPD3 Promotes Diffuse Large B-Cell Lymphoma Progression Through Modulating SIRT1 Expression in an H3K9 Monomethylation-Dependent Manner

Medicine, Hematology, Oncology, Life Sciences, Immunology,
NCAPD3   chromatin conformation   SIRT1   H3K9 monomethylation   diffuse large B-cell lymphoma   transcription regulation   mitosis  

Study on the Pro-Cancer Mechanism and Application Value of NCAPD3 in Diffuse Large B-Cell Lymphoma Academic Background Diffuse large B-cell lymphoma (DLBCL) is the most common hematological malignancy, characterized by significant clinical and biological heterogeneity. Although advances in treatment have been made in recent years, a subset of patie...

Unlocking Melanoma Suppression: Insights from Plasma-Induced Potent miRNAs through PI3K-AKT-ZEB1 Axis

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Non-thermal plasma   miRNA sequencing   Differential regulation   Melanoma inhibition   PI3K-AKT-ZEB1 axis  

Study on Melanoma Suppression by Non-Thermal Atmospheric Pressure Plasma via the PI3K-AKT-ZEB1 Axis Academic Background Melanoma is the most aggressive and deadly form of skin cancer, particularly in its advanced stages, making treatment extremely challenging. Although recent advancements in targeted therapy and immunotherapy have improved patient ...

Inflammatory Proteins and Hidradenitis Suppurativa: Insights from Genetic Correlation and Mendelian Randomization

Medicine, Life Sciences, Immunology, Genetics, Microbiology,
Hidradenitis Suppurativa   Inflammatory Proteins   Genetic Correlation   Mendelian Randomization   Causal Relationship  

Inflammatory Proteins and Hidradenitis Suppurativa: Insights from Genetic Correlation and Mendelian Randomization Studies Research Background Hidradenitis Suppurativa (HS) is a chronic inflammatory skin disease characterized by recurrent nodules, abscesses, and sinus tracts, commonly found in areas of skin friction such as the armpits, groin, peria...

Prognostic Value of the CONUT Score with Immune Checkpoint Inhibitors as First-Line Therapy for Metastatic Malignant Melanoma

Medicine, Oncology, Life Sciences, Immunology,
Immune checkpoint inhibitors   Nutritional status   Melanoma   Prognostic marker   Inflammation  

Prognostic Value of the CONUT Score in Immune Checkpoint Inhibitor Therapy for Metastatic Malignant Melanoma Academic Background The incidence of malignant melanoma (MM) is increasing annually, with approximately 20% of patients progressing to advanced or metastatic melanoma. Immune checkpoint inhibitors (ICIs) have significantly transformed the tr...

Prevalence and Incidence of Comorbidities in Patients with Atopic Dermatitis, Psoriasis, Alopecia Areata, and Vitiligo Using a Japanese Claims Database

Medicine, Infectious Diseases, Rheumatology and Immunology, Oncology, Cardiovascular System, Life Sciences, Immunology,
comorbidities   atopic dermatitis   psoriasis   alopecia areata   vitiligo   Japan   health claims database  

Prevalence and Incidence of Comorbidities in Japanese Patients with Dermatologic Diseases Academic Background Dermatologic diseases such as atopic dermatitis (AD), psoriasis, alopecia areata (AA), and vitiligo are common chronic inflammatory or autoimmune skin disorders. These conditions not only significantly impact patients’ quality of life but a...

Infiltration of M2a Macrophages is Predominant in Genital Verruciform Xanthoma

Medicine, Life Sciences, Immunology,
M2a macrophages   verruciform xanthoma   genital   immunohistochemistry   pathology  

Predominant Infiltration of M2a Macrophages in Genital Verruciform Xanthoma Academic Background Verruciform xanthoma (VX) is a rare benign verrucous tumor first reported by Sachs in 1903 and formally named by Shafer in 1971. This lesion primarily occurs in the genital area and oral mucosa of elderly individuals. Histopathologically, it is character...