Syntaxin 4-Enhanced Plasma Membrane Repair is Independent of Dysferlin in Skeletal Muscle Background Introduction Plasma membrane repair (PMR) is a crucial process for cells to maintain membrane integrity, preventing cell death, especially in vital organs such as skeletal muscle. Dysferlin, a sarcolemmal calcium-binding protein, has been shown to p...

Mechanism Study of p300 Maintaining Primordial Follicle Activation by Inhibiting VEGFA Transcription Academic Background In the female reproductive system, primordial follicles (PFs) are the earliest formed follicles in the ovary, remaining dormant and awaiting activation to enter the growth phase. The activation of primordial follicles is a key fa...

Mechanism Study of Dapagliflozin Improving Diabetic Nephropathy via the Gut-Kidney Axis Academic Background Diabetic nephropathy (DN) is one of the most common microvascular complications of diabetes, with approximately 40% of individuals with type 1 or type 2 diabetes developing DN in the advanced stages of the disease. Although clinical managemen...

Chronic Kidney Disease: Runx2-NLRP3 Axis Regulates Matrix Stiffness-Induced Vascular Smooth Muscle Cell Inflammation Academic Background Chronic Kidney Disease (CKD) is a common condition worldwide, leading to high morbidity and mortality rates among patients and significantly increasing the risk of cardiovascular events. Arterial stiffening, chara...

Retrieval of Conditioned Immune Response in Mice is Mediated by an Anterior-Posterior Insular Circuit Academic Background The bidirectional relationship between the brain and the immune system is a cornerstone of philosophical and scientific research. In recent years, researchers have identified multiple pathways through which the immune system inf...

Study on the Propagation of Neuronal Micronuclei Regulating Microglial Characteristics Academic Background Microglia, the resident immune cells in the central nervous system (CNS), play a crucial role in maintaining brain homeostasis, regulating neuronal development, synaptic pruning, and responding to pathological states. However, despite extensiv...