Coactivation of Innate Immune Suppressive Cells Induces Acquired Resistance Against Combined TLR Agonism and PD-1 Blockade

Medicine, Oncology, Life Sciences, Immunology,
innate immune suppressive cells   acquired resistance   TLR agonists   PD-1 blockade   tumor microenvironment   CXCL1-CXCR2 axis   polymorphonuclear myeloid-derived suppressor cells  

Mechanism of Combined Immune Checkpoint Blockade Therapy Academic Background Immune Checkpoint Blockade (ICB) is a revolutionary cancer treatment aimed at reactivating effector T cells to combat cancer. However, more than half of patients do not respond to ICB, especially those with immunologically “cold” tumors (tumors with fewer immune cells in t...

Organ-Specific Microenvironments Drive Divergent T Cell Evolution in Acute Graft-Versus-Host Disease

Medicine, Rheumatology and Immunology, Hepatobiliary System, Respiratory System, Gastroenterology, Hematology, Life Sciences, Immunology,
Graft-versus-host disease   T cell evolution   Organ microenvironment   Immunopathology   Single-cell RNA sequencing  

Study on Organ-Specific T Cell Differentiation in Acute Graft-Versus-Host Disease (AGVHD) Academic Background Acute Graft-Versus-Host Disease (AGVHD) is a common and severe complication following Allogeneic Hematopoietic Stem Cell Transplantation (HCT), caused by the immune attack of donor T cells on host tissues. Although the pathological mechanis...

Triple Knockdown of CD11a, CD49d, and PSGL1 in T Cells Reduces CAR-T Cell Toxicity but Preserves Activity Against Solid Tumors in Mice

Medicine, Oncology, Life Sciences, Cell Biology, Immunology,
CAR-T cells   solid tumors   immunotherapy   cell adhesion   cell migration  

Study on Reducing Toxicity of CAR-T Cell Therapy for Solid Tumors Academic Background Chimeric antigen receptor T-cell (CAR-T) therapy has made significant progress in treating hematologic malignancies, but its application in solid tumors faces major challenges. Solid tumors often lack tumor-specific antigens (TSAs), and CAR-T cells may attack norm...

Selective Abrogation of S6K2 Identifies Lipid Homeostasis as a Survival Vulnerability in MAPK Inhibitor–Resistant NRAS-Mutant Melanoma

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
NRAS-mutant melanoma   MAPK inhibitor resistance   lipid metabolism   S6K2   PPARα  

Academic Background NRAS-mutant (NRASmut) melanoma is a highly aggressive tumor type, accounting for nearly 30% of all melanoma cases. NRAS is an oncogene that persistently activates the mitogen-activated protein kinase (MAPK) signaling pathway, which plays a critical role in melanoma development. However, despite extensive research on MAPK pathway...

Pseudomonas aeruginosa Infection Induces Lung Transplant Antibody-Mediated Rejection

Medicine, Infectious Diseases, Life Sciences, Immunology,
Pseudomonas aeruginosa   lung transplantation   antibody-mediated rejection   lymphocytotoxicity   bacterial infection  

Pseudomonas aeruginosa Infection Induces Antibody-Mediated Rejection in Lung Transplantation Academic Background Introduction Lung transplantation is a critical treatment for end-stage lung diseases, but post-transplant rejection remains a major challenge affecting long-term patient survival. Antibody-mediated rejection (AMR) is an increasingly rec...

Age-Dependent Macropinocytosis Drives Resistance to KRAS-G12D–Targeted Therapy in Advanced Pancreatic Cancer

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Pancreatic Cancer   KRAS-G12D   Macropinocytosis   Drug Resistance   Targeted Therapy  

Academic Background and Problem Pancreatic Ductal Adenocarcinoma (PDAC) is an aggressive cancer with an extremely low five-year survival rate, primarily due to late diagnosis and limited treatment options. Approximately 95% of PDAC patients harbor KRAS mutations, with the KRAS-G12D mutation being the most common. Although KRAS mutations have long b...