Academic Background and Problem Pancreatic Ductal Adenocarcinoma (PDAC) is an aggressive cancer with an extremely low five-year survival rate, primarily due to late diagnosis and limited treatment options. Approximately 95% of PDAC patients harbor KRAS mutations, with the KRAS-G12D mutation being the most common. Although KRAS mutations have long b...

Study on Congenital Immune Dysfunction in Cystic Fibrosis Research Background Cystic Fibrosis (CF) is a genetic disease caused by mutations in the CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) gene, primarily affecting the lungs and digestive system. One of the major problems faced by CF patients is recurrent infections and inflammatio...

Functional Plasticity of Human MAIT Cells and Their Role in Immune Regulation Academic Background Mucosal-Associated Invariant T cells (MAIT cells) are a type of unconventional T lymphocyte found abundantly in healthy humans, especially in mucosal tissues. MAIT cells exhibit innate-like characteristics, rapidly recognizing antigens derived from mic...

Research Background Current Status and Challenges in Hidradenitis Suppurativa Research Hidradenitis Suppurativa (HS) is a relatively common and highly morbid inflammatory skin disease. It affects approximately 1% of the global population, disproportionately impacting women and marginalized groups. HS’s pathogenesis is complex, involving genetic, im...

Promoting Healthy Longevity: Implementation Recommendations for the Hevolution Alliance for Aging Biomarkers Initiative Academic Background and Research Motivation With the intensification of global population aging, human life expectancy has significantly increased, but the growth in healthy life expectancy (i.e., years lived in good health) has b...

Cancer Cells Evade Immune Cell-Induced Ferroptosis via Fatty Acid Binding Protein 7 Background Introduction Cancer creates an immunosuppressive environment that hinders immune responses, allowing tumors to grow and resist treatment. The immune system combats this by inducing ferroptosis in tumor cells through CD8+ T cells. Ferroptosis is a type of ...