Inflammatory Mechanisms in Traumatic Brain Injury and Post-Traumatic Epilepsy: A Study

Medicine, Rheumatology and Immunology, Neurology, Neurosurgery, Life Sciences, Biochemistry, Immunology,
Traumatic Brain Injury   Post-Traumatic Epilepsy   Inflammasome Signaling   Microglia   NLRP3  

Neuroinflammation and Epilepsy: The Role of Inflammasomes in Traumatic Brain Injury Background and Purpose Traumatic Brain Injury (TBI) refers to changes in brain function and pathology resulting from physical trauma to the head or neck. Apart from common behavioral and psychological disorders, post-traumatic epilepsy (PTE) is one of the most sever...

The impact of high-fat diet on microglial cells and its effects on brain function

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
obesity   neuroinflammation   energy metabolism   glycolysis   extracellular vesicles  

Research on Saturated Fatty Acids and Brain Function Background Introduction Obesity and metabolic syndrome are major global health challenges today. Numerous studies have shown that excessive consumption of diets rich in saturated fats leads to obesity, accompanied by a series of metabolic complications such as insulin resistance and diabetes. How...

Early Depletion of Gut Microbiota Shapes Oligodendrocyte Response After Traumatic Brain Injury

Medicine, Rheumatology and Immunology, Neurology, Neurosurgery, Life Sciences, Cell Biology, Immunology, Microbiology,
Traumatic Brain Injury   White Matter Injury   Gut Microbiota   T Cells   Oligodendrocytes   Neuroinflammation   Remyelination  

Study on the Role of Gut Microbiota in White Matter Repair after Traumatic Brain Injury - Analysis of “Journal of Neuroinflammation” Introduction Every year, around 1.7 million people in the United States experience traumatic brain injury (TBI), with over 5 million facing disability issues related to TBI. These non-fatal TBIs are estimated to incur...

Park7/DJ-1 Deficiency Impairs Microglial Activation in Response to LPS-Induced Inflammation

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Park7/DJ-1   lipopolysaccharide   microglia   neuroinflammation   Parkinson's disease   microglia morphology  

Important Research Interpretation from “Journal of Neuroinflammation” 2024: The Impact of Park7/DJ-1 Deficiency on Microglial Activation Academic Background Parkinson’s Disease (PD) is the second most common neurodegenerative disease, characterized by the accumulation of α-synuclein and progressive loss of dopaminergic neurons. Aging is the primary...

Integrating Single-Nucleus RNA Sequencing and Spatial Transcriptomics to Elucidate a Specialized Subpopulation of Astrocytes, Microglia, and Vascular Cells in a Mouse Model of Lipopolysaccharide-Induced Sepsis-Associated Encephalopathy

Medicine, Infectious Diseases, Neurology, Life Sciences, Cell Biology, Immunology,
sepsis   sepsis-associated encephalopathy   single-nucleus RNA sequencing   spatial transcriptomics   ANXA1   glial cell response   cellular localization  

Study on Mouse Sepsis-Associated Encephalopathy Based on Single Cell and Spatial Transcriptomics Background Organ dysfunction leading to death in sepsis is related to an imbalance in the host’s response to infection, and it has a high global mortality rate. Recent studies have shown that sepsis can cause brain dysfunction, known as sepsis-associate...

Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury

Medicine, Neurology, Ophthalmology, Life Sciences, Biochemistry, Immunology,
retinal ischemia-reperfusion injury   histone deacetylase 3   microglia   macrophages   efferocytosis  

The Role of HDAC3 in Retinal Ischemia-Reperfusion Injury Background Retinal ischemia-induced retinal diseases are significant characteristics of common visual impairments such as diabetic retinopathy (DR) and central retinal artery and vein occlusion. The therapeutic effects for these ischemic retinal diseases are generally ineffective, and the des...