The Protective Roles of Integrin α4β7 and Amphiregulin-Expressing Innate Lymphoid Cells in Lupus Nephritis

Medicine, Rheumatology and Immunology, Nephrology, Life Sciences, Immunology,
innate lymphoid cells   tissue residency   adhesion molecules   integrins   kidney   lupus nephritis   amphiregulin  

Scientific Research Report: The Protective Role of Integrin α4β7 and Type 2 Innate Lymphoid Cells in Nephritis In a recent study, an international research team led by Dr. Seungwon Ryu revealed the critical protective role of integrin α4β7 and Type 2 Innate Lymphoid Cells (ILC2s) in nephritis caused by Systemic Lupus Erythematosus (SLE). The study ...

An antibody that inhibits TGF-β1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis

An antibody that inhibits TGF-β1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis

Medicine, Rheumatology and Immunology, Hepatobiliary System, Nephrology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
antibody   TGF-β1   renal fibrosis   latent extracellular matrix   selective inhibition  

Study of TGF-β1 in Fibrosis Progression: An Exploration of an Antibody Targeting Binding Proteins Research Background Fibrosis is a leading cause of poor prognosis in numerous diseases, such as chronic kidney disease, non-alcoholic steatohepatitis, and idiopathic pulmonary fibrosis. Despite the substantial medical need, directly targeting fibrosis ...

Targeting T cell plasticity in kidney and gut inflammation by pooled single-cell CRISPR screening

Targeting T cell plasticity in kidney and gut inflammation by pooled single-cell CRISPR screening

Medicine, Rheumatology and Immunology, Nephrology, Gastroenterology, Life Sciences, Immunology,
T cells   plasticity   kidney inflammation   gut inflammation   single-cell CRISPR   autoimmune diseases  

Targeting T Cell Plasticity to Treat Inflammation in the Kidney and Gut: A Study Using Pooled Single-cell CRISPR Screening Background of the Study This paper, co-authored by Leon U.B. Enk and others, was published in the June 14, 2024, issue of “Science Immunology” under the title “Targeting T cell plasticity in kidney and gut inflammation by poole...