NUMB Gene Variant: A Novel Mechanism in Gout Development Background Gout is one of the most common forms of inflammatory arthritis worldwide, primarily triggered by the persistent elevation of serum uric acid levels, known as hyperuricemia. Hyperuricemia leads to the deposition of urate crystals, resulting in inflammation of joints and other tissue...

Systematic Multi-Omics Analysis and In Vitro Experiments Suggest ITGA5 as a Potential Target for Clear Cell Renal Cell Carcinoma (ccRCC) Treatment Research Background and Motivation Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma (RCC), accounting for about 75% of all kidney cancer cases. According to the ...

Sexual Dimorphism in the Mouse Kidney-Brain Connectome In recent years, an increasing number of studies have shown that kidney function is not only influenced by local self-regulation and hormonal systems but is also largely regulated by the nervous system. Although it is known that there are multi-synaptic anatomical connections between central au...

Special Report: The Role of Tissue-Resident Memory T Cells in Breaking Self-Antigen Immune Tolerance and Immune-Mediated Nephritis in the Kidney Introduction Immune-mediated nephritis is one of the major causes of acute kidney injury and chronic kidney disease. While the role of B cells and antibodies in such diseases has been extensively studied, ...

Preface Chronic Kidney Disease (CKD) is a condition characterized by long-term damage to kidney structure, leading to gradual loss of kidney function. Currently, about 10% of adults worldwide are affected by CKD, causing approximately 1.2 million deaths annually. Renal fibrosis is one of the pathological manifestations of CKD, characterized by the ...