In recent years, autophagy, as a crucial intracellular degradation and recycling mechanism, has played a key role in maintaining cellular homeostasis and responding to various stress conditions. Particularly in renal proximal tubular epithelial cells, autophagy activity is essential for coping with common renal injuries such as ischemia, toxic dama...

Academic Background Renal Cell Carcinoma (RCC) is one of the cancers with a rapidly rising incidence globally, particularly among young patients and minorities. In the United States, an estimated 81,610 new cases of RCC will be diagnosed in 2024, with approximately 30% progressing to metastatic RCC. For locally advanced RCC, the initial treatment i...

Research Background Hypertension is one of the most common and serious health problems worldwide, with its high prevalence closely linked to an increased risk of cardiovascular diseases and stroke. Although the pathogenesis of hypertension is complex and involves multiple organs or systems (such as the kidneys, arteries, microcirculation, heart, an...

The Impact of Persistent Severe Acute Kidney Injury on Outcomes in Critically Ill Patients Background Introduction Acute Kidney Injury (AKI) is a common complication among hospitalized and critically ill patients, causing over 10 million deaths globally each year and serving as a significant risk factor for the progression of Chronic Kidney Disease...

The Role of Major Cardiovascular Surgery-Induced Metabolic Reprogramming in Acute Kidney Injury: A Metabolomics Study Academic Background Cardiovascular diseases are the leading cause of death worldwide, accounting for over 17.9 million deaths annually, which is 32% of all deaths. As the disease burden increases, about one-third of patients may req...