Mechanistic Analysis of Channel Dysfunction Caused by Diverse Pathogenic Polycystin Pore Helix Variants

Medicine, Basic Medical Sciences, Nephrology, Life Sciences, Cell Biology, Biochemistry, Genetics, Biophysics,
autosomal dominant polycystic kidney disease   polycystin   channelopathy   ion channel   primary cilia   structure   drug development  

I. Research Background and Scientific Significance Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common monogenic hereditary kidney disease that affects millions of people worldwide. ADPKD is primarily caused by mutations in the renal polycystin family (especially the PKD1 and PKD2 genes), which encode channel subunits pivotal for ion c...

Local and Distal Dynamic Changes Caused by the L205R Cushing’s Syndrome Mutant in PRKACA

Medicine, Endocrinology, Life Sciences, Cell Biology, Biochemistry, Biophysics,
L205R mutation   Cushing’s syndrome   protein kinase A   molecular dynamics simulation   local spatial pattern   protein residue networks  

New Insights into the Molecular Dynamics and Allosteric Network Regulation Mechanisms of the Common Cushing’s Syndrome Mutation L205R in Protein Kinase A: Interpreting the Latest Original Research from PNAS I. Research Background and Scientific Questions Protein kinase A (PKA) is a key intracellular signal transduction molecule that regulates a var...

Cross-species modeling of plant genomes at single-nucleotide resolution using a pretrained DNA language model

Information Science, Computer Science, Artificial Intelligence, Life Sciences, Biochemistry, Bioengineering, Genetics, Botany,
plant genomics   deep learning   DNA language model   cross-species prediction   deleterious mutation   gene annotation   angiosperm  

A Milestone in Cross-Species Modeling of Plant Genomes: Creation and Breakthrough Application of the PlantCaduceus DNA Language Model I. Academic Background and Research Motivation In the past two decades, with the rapid development of high-throughput sequencing technology, over 1,000 plant genomes have been published, and this number is expected t...

A Specific Negatively Charged Sequence Confers Intramolecular Regulation on Munc13-1 Function in Synaptic Exocytosis

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Biophysics,
Munc13-1   synaptic exocytosis   negatively charged sequence   autoinhibition   calcium regulation   protein structure   neurotransmitter release  

Unlocking a New Mechanism for the Regulation of Neurotransmitter Release: A Review of Munc13-1’s Novel Autoinhibitory Structure and Its Calcium-Modulated Role I. Academic Background and Research Motivation Signal transmission between neurons relies on chemical synapses, with precise neurotransmitter release from presynaptic terminals via synaptic e...

Amortized Template Matching of Molecular Conformations from Cryoelectron Microscopy Images Using Simulation-Based Inference

Information Science, Artificial Intelligence, Medicine, Medical Imaging, Life Sciences, Cell Biology, Biochemistry, Biophysics,
cryo-EM   biophysics   Bayesian inference   molecular modeling   template matching   deep learning   structural biology  

Accelerating Single-Molecule Structure Identification with Simulation-Based Inference — Research Report on “Amortized Template Matching of Molecular Conformations from Cryoelectron Microscopy Images using Simulation-Based Inference” Research Background and Significance In the fields of molecular biology and structural biology, understanding how bio...