In the field of functional genomics, researchers have long been dedicated to predicting causal regulatory relationships from observational data. However, despite modern technologies enabling the measurement of diverse molecular modalities, inferring causal regulatory relationships from observational data remains challenging. In particular, the iden...

The occurrence and progression of cancer are closely related to the expression of oncogenes, and the regulation of oncogene expression is a complex process. Among these mechanisms, the role of translation control in oncogene expression has gradually gained attention. MYC is a key oncogene that is overexpressed in various cancers, particularly in pa...

Research Background During the early stages of mammalian embryonic development, embryonic cells gradually differentiate into various cell types through complex regulatory mechanisms, forming tissues with specific functions. This process is known as tissue patterning, which involves the determination of cell fate, coordination of cellular dynamics, ...

Kaposi’s sarcoma-associated herpesvirus (KSHV) is a γ-herpesvirus that primarily infects endothelial cells and leads to the development of Kaposi’s sarcoma (KS), especially in people living with HIV. Kaposi’s sarcoma is a malignant tumor characterized by endothelial cell proliferation, typically presenting as cutaneous lesions. After infecting endo...

Skin wound healing is a complex biological process involving the coordination of cellular, molecular, and physiological events. Although traditional treatment methods can promote wound closure to some extent, their efficacy is often unsatisfactory in chronic wounds or complex trauma environments, particularly in controlling infections and inflammat...

Intervertebral Disc Degeneration (IVDD) is one of the leading causes of low back pain worldwide, significantly impacting patients’ quality of life. IVDD is often accompanied by inflammatory responses, leading to the degradation of the extracellular matrix (ECM) and structural damage. Although cell therapies, such as mesenchymal stem cells (MSCs), h...