Inferring Gene Regulatory Networks from Time-Series scRNA-Seq Data via Granger Causal Recurrent Autoencoders

Information Science, Computer Science, Artificial Intelligence, Life Sciences, Cell Biology, Genetics,
scRNA-seq   gene regulatory network   unsupervised learning   Granger causality   recurrent variational autoencoder  

1. Academic Background and Research Motivation In recent years, single-cell RNA sequencing (scRNA-seq) has become one of the most groundbreaking technologies in life sciences and medical research, enabling researchers to capture subtle differences in transcript levels among numerous cells at the resolution of individual cells. This technology has g...

In Situ Architecture of the Human Prohibitin Complex

Life Sciences, Cell Biology, Biophysics,
prohibitin complex   mitochondrial inner membrane   structural biology   cryo-electron tomography   molecular modeling  

Academic Background Mitochondria are the energy factories of cells, and the integrity of the mitochondrial inner membrane (MIM) is crucial for cellular function. Prohibitin (PHB) is a highly conserved protein family, consisting of two subtypes, PHB1 and PHB2, which play important roles in various cellular processes, including mitochondrial stress s...

Modulation of Bone Marrow Haematopoietic Stem Cell Activity as a Therapeutic Strategy After Myocardial Infarction: A Preclinical Study

Medicine, Hematology, Cardiovascular System, Life Sciences, Cell Biology, Immunology,
myocardial infarction   bone marrow haematopoietic stem cells   inflammation   vitamin A metabolites   cardiac function  

Academic Background Myocardial Infarction (MI) is one of the major global health concerns. Although myeloid cells in the bone marrow (BM) are crucial for tissue repair after MI, excessive myelopoiesis can exacerbate scarring and impair cardiac function. Hematopoietic stem cells (HSCs) in the bone marrow possess unique regenerative capabilities, ena...

PRMT5-mediated arginine methylation stabilizes GPX4 to suppress ferroptosis in cancer

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry,
ferroptosis   PRMT5   GPX4   cancer therapy   methylation   tumor progression   antioxidant  

Background Introduction Ferroptosis is a form of cell death triggered by iron-dependent lipid peroxidation, which has recently been recognized as having significant potential in cancer therapy. Cancer cells evade ferroptosis through various molecular alterations and metabolic reprogramming mechanisms, with glutathione peroxidase 4 (GPX4) being a ke...

A Quantitative Ultrastructural Timeline of Nuclear Autophagy Reveals a Role for Dynamin-like Protein 1 at the Nuclear Envelope

Life Sciences, Cell Biology,
nuclear autophagy   dynamin-like protein 1   nuclear envelope   ultrastructure   yeast   membrane fission   cellular homeostasis  

Background Introduction The nuclear envelope (NE) is a critical barrier between the nucleus and the cytoplasm, responsible for maintaining the stability of the nuclear environment. The integrity of the nuclear envelope is essential for normal cellular function, and its disruption is closely linked to aging and various diseases. Autophagy is a vital...

ADSL-Generated Fumarate Binds and Inhibits STING to Promote Tumour Immune Evasion

Medicine, Oncology, Life Sciences, Cell Biology, Immunology,
tumour immune evasion   STING inhibition   ADSL   fumarate   breast cancer  

Research Background In the tumor microenvironment, highly aggressive tumors evade immune system attacks by suppressing the cGAS-STING signaling pathway. The cGAS-STING pathway is a critical mechanism for cells to sense cytoplasmic double-stranded DNA and initiate immune responses. cGAS (cyclic GMP-AMP synthase) catalyzes the production of cGAMP upo...