Study on the Propagation of Neuronal Micronuclei Regulating Microglial Characteristics Academic Background Microglia, the resident immune cells in the central nervous system (CNS), play a crucial role in maintaining brain homeostasis, regulating neuronal development, synaptic pruning, and responding to pathological states. However, despite extensiv...

New Discoveries in Astrocyte Regulation of Behavior: Application of the AstroLight Tool Academic Background For a long time, neuroscience research has primarily focused on neuronal activity, while neglecting the role of astrocytes in brain function. Although astrocytes are one of the most numerous cell types in the brain, they have traditionally be...

NOMPC Ion Channel Hinge Forms Gating Spring to Initiate Mechanosensation Academic Background Mechanosensation is the process by which organisms perceive external mechanical stimuli and convert them into electrical signals. This process plays a crucial role in touch, hearing, gravity perception, and the movement of internal organs and limbs. The ini...

Aberrant Splicing in Huntington’s Disease Accompanies Disrupted TDP-43 Activity and Altered m6A RNA Modification Academic Background Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder characterized by motor, cognitive, and psychiatric symptoms. The disease is caused by a CAG repeat expansion in the HTT gene, leading to ab...

Study on the Hypothalamus-Habenula Circuit Regulating Risk Preference Academic Background In complex and uncertain environments, animals need to assess risks to make survival-favorable decisions. When faced with safe and risky options, animals usually exhibit a strong preference for one option, which remains consistent over time. However, how this ...

Functional Segregation of Dopaminergic Neural Circuits and Their Developmental Mechanisms Academic Background Dopamine is a crucial neurotransmitter in the brain, regulating various physiological functions, including motor control, emotional regulation, motivation, learning, and memory. Dopaminergic neurons are primarily located in the midbrain, an...